KEVIN K. CALDWELL, Ph.D.  Assistant Professor Department of Neurosciences

Education and Honors:
1976-1982, Bachelor of Science, Pharmacy, University of Kansas School of Pharmacy, Lawrence, Kansas,1983-1988 Predoctoral Graduate Student, Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado, 1988-1993, Postdoctoral Research Associate, Division of Hematology-Oncology, Washington University School of Medicine, St. Louis, Missouri, 1993-1997, Research Assistant Professor, Department of Pathology, University of New Mexico School of Medicine, Albuquerque, New Mexico, 1993-present, Associate Scientist, University of New Mexico Cancer Research and Treatment Center, Albuquerque, New Mexico; 1997-2000, Research Assistant Professor, Department of Neurosciences, UNM Health Sciences Center, Albuquerque, NM.; 2000-present,  Assistant Professor, Department of Neurosciences, UNM Health Sciences Center, Albuquerque, NM; 1982, Research Society on Alcoholism Travel Award; 1996, University of New Mexico Apple for the Teacher Award, Graduate Studies (Medical Sciences).

Research Interests:
The overall goal of my research is to help elucidate the signal transduction systems that are required for learning and memory and to define their roles in various cognitive dysfunctions, including those resulting from prenatal exposure to ethanol.

Selected Publications:

Caldwell, K.K., Lips, D.L., Bansal, V.S., and Majerus, P.W. (1991) Isolation and characterization of two 3-phosphatases that hydrolyze both phosphatidylinositol 3-phosphate and inositol 1, 3-bisphosphate. J. Biol. Chem. 266, 18378-18386.

Barker, S.A., Caldwell, K.K., Hall, A., Martinez, A.M., Pfeiffer, Oliver, J.R, and Wilson, J.M., B.S. (1995). Wortmannin blocks lipid and protein kinase activities associated with PI 3-kinase and inhibits a subset of responses induced by Fc,R1 crosslinking.Mol. Biol. Cell 6: 1145-1158.

Allan, A.M., Weeber, E.J., Savage, D.D. and Caldwell, K.K. (1997). Prenatal exposure to moderate doses of ethanol diminishes phospholipase C b1- and phospholipase A2-dependent signaling in adult rat brain prefrontal cortex and hippocampus. Alcohol Clin Exp Res 21: 1534-1541.

Tannheimer, S.L., Ethier, S.P., Caldwell, K.K., Burchiel, S.W. (1998) Benzo[a]pyrene- and TCDD-induced alterations in tyrosine phosphorylation and insulin-like growth factor signaling pathways in the MCF-10A human mammary epithelial cell line. Carcinogenesis 19:1291-1297.

Barker, S.A., Caldwell, K.K., Pfeiffer, J.R., Wilson, B.S. (1998) Wortmannin-sensitive phosphorylation, translocation and activation of PLC g1, PLCg2, in antigen-stimulated RBL-2H3 mast cells.  Mol. Biol. Cell 9:483-496.

Munday, A.D., Norris, F.A., Caldwell, K.K., Brown, S., Majerus, P.w., Mitchell, C.A. (1999) The inositol polyphosphate 4-phosphatase forms a complex with phosphatidylinositol 3-kinase in human platelet cytosol. Proc. Natl. Acad. Sci USA 96:3640-3645.

Weeber, E.J., Savage, D.D., Sutherland, R.S., Caldwell, K.K. Fear conditioning-induced alterations of phospholipase C-b1a protein level and enzyme activity in rat hippocampal formation and medial frontal cortex.  Neurobiology of Learning and Memory 76, 151-182.

Nandurkar, H.H., Caldwell, K.K., Whisstock, J.C., Layton, M.J., Gaudet, E.A., Norris, F.A., Majerus, P.W., and Mitchell, C.A.  (2001)  Characterization of an adapter subunit to a phosphatidylinositol (3)P 3-phosphatase: Identification of a myotubularin-related protein lacking catalytic activity. Proc. Natl. Acad. Sci. USA. 98, 9499-9504.

Nandurkar, H.H., Layton, M., Laporte, J. Selan, C., Corcoran, L., Caldwell, K.K., Mochizuki, Y., Majerus, P.W., Mitchell, C.A. (2003) Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP. Proc. Natl. Acad. Sci. USA 100:8660-8665.

Buckley, C.T. and Caldwell, K.K. (2003) Two-layer antibody capture of enzymes on the surface of microtiter plates: application to the study of the regulation of phospholipase C-?1 catalytic activity Anal. Biochem. 320: 193-198.

Allan, A.M., Chynoweth, J., Tyler, L.A., and Caldwell, K.K. (2003) A mouse model of prenatal ethanol exposure using a voluntary drinking paradigm. Alcohol. Clin. Exp. Res 27, 2009-2016.

Weeber, E.J. and Caldwell, K.K. (2004) Delay fear conditioning modifies phospholipase C-?1a signaling in the hippocampus and frontal cortex. Pharmacol. Biochem. Behav. 78, 155-164.

Galindo, R., Frausto S., Wolff, C., Caldwell, K.K., Perrone-Bizzozero, N.I., and Savage, D.D. (2004, in press) Prenatal ethanol exposure reduces mGluR5 receptor number and function in the dentate gyrus of adult offspring. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15597093&query_hl=21&itool=pubmed_docsum

Buckley, C.T., Sekiya, F., Kim, Y.J., Rhee, S.G., Caldwell, K.K. (2004) Identification of phospholipase C-?1 as a mitogen-activated protein kinase substrate. J. Biol. Chem 279: 41807-41814.

Buckley, C.T., Caldwell K.K. (2004) Fear conditioning is associated with altered integration of PLC and ERK signaling in the hippocampus. Pharmacol Biochem Behav. 2004 Dec;79(4):633-40.

Caldwell KK, Sosa M, Buckley CT (2006) Identification of mitogen-activated protein kinase docking sites in enzymes that metabolize phosphatidylinositols and inositol phosphates. Cell Commun Signal. 4(1):2.

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