The pie charts within each grid sector of Figure 1 (click to enlarge), shows the approximate proportion of argyrophilic neurons at 24 hours after injury that are likely to die. Note that there are many more argyrophilc neurons in the deep lamina of the lateral sectors. Figure 2  (click to enlarge) illustrates an abundance of argyrophilic neurons 24 hours after injury as were found in the the deep lateral sectors. At our late data point (not shown), three days after injury 14 of the 15 animals studied had at least one of the nine sample points rated 25%-100% of neurons rated as normal. Also at the last time point sampled. 72 hrs after TBI, only a few neurons appeared to be in an early stage of argyrophylic reaction. The rCBF data at 24 hours after injury showed an area of severe ischemia, but above threshold for neuronal death, (25+ % of control at the site of injury and areas of hyperemia detected in striatum and dorsal hippocampus. (163+24% and 138+9 of control respectively). (See Figure 3). Lastly the reconstruction of the cyst illustrated in Figure 4  (click to enlarge) shows the sparing of contused cortex on the midline of the hemisphere and the lateral spread of the necrosis.
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