The pie charts within each grid sector of Figure
to enlarge), shows the approximate proportion of argyrophilic neurons
at 24 hours after injury that are likely to die. Note that there are many
more argyrophilc neurons in the deep lamina of the lateral sectors.
to enlarge) illustrates an abundance of argyrophilic neurons 24 hours
after injury as were found in the the deep lateral sectors. At our late
data point (not shown), three days after injury 14 of the 15 animals studied
had at least one of the nine sample points rated 25%-100% of neurons rated
as normal. Also at the last time point sampled. 72 hrs after TBI, only
a few neurons appeared to be in an early stage of argyrophylic reaction.
The rCBF data at 24 hours after injury showed an area of severe ischemia,
but above threshold for neuronal death, (25+ % of control at the site of
injury and areas of hyperemia detected in striatum and dorsal hippocampus.
(163+24% and 138+9 of control respectively). (See
Figure 3). Lastly the
of the cyst illustrated in Figure 4
to enlarge) shows the sparing of contused cortex on the midline of
the hemisphere and the lateral spread of the necrosis.
Poster Title Page | Introduction
| Methods | Conclusion