Research Interests:
I am interested in the role of the immune system in muscle plasticity and exercise. During my PhD, I studied cytokines and immune cells in the context of a muscle damage and repair. As a post-doc at the University of Florida, I applied my interest in immunology and skeletal muscle to study cytokines and suppressive immune cells in the development and progression of cancer-induced muscle wasting (cachexia). My ongoing research focuses on immunological factors in cancer cachexia, muscle damage, muscle adaptation, as well as anti-inflammatory and anti-catabolic effects of exercise.

Selected Publications:
Neyroud D, D'Lugos AC, Trevino EJ, Callaway CS, Lamm J, Laitano O, Poole B, Deyhle MR, Brantley J, Le L, Judge AR, Judge SM. Local Inflammation Precedes Diaphragm Wasting and Fibrotic Remodelling in a Mouse Model of Pancreatic Cancer. J Cachexia Sarcopenia Muscle. 2025;16(1):e13668.

Ducharme JB, Specht JW, Bailly AR, Fennel ZJ, Nava RC, Mermier CM, Laitano O, Deyhle MR. Training Status Influences Regulation of Muscle and PBMC TLR4 Expression and Systemic Cytokine Responses to Vigorous Endurance Exercise. Med Sci Sports Exerc. 2024.

Leslie E, Gonzalez Bosc LV, Specht J, McKenna ZJ, Gridley R, Luna V, Jones DT, Lantz BJ, Moriwaki M, Hsiao YY, Gibson AL, Mermier C, Wilson SM, Deyhle MR. Impact of Maternal Exercise on Mice Offspring Development, Pulmonary Hypertension, and Vascular Remodeling in Chronic Hypoxia. Med Sci Sports Exerc. 2024.

Deyhle MR, Tiede D, Xin L, Hyldahl RD, Hubal MJ. Common Markers of Muscle Damage are Associated with Divergent Gene Expression Patterns after Eccentric Contractions. Med Sci Sports Exerc. 2024.

Ducharme JB, McKenna ZJ, Specht JW, Fennel ZJ, Berkemeier QN, Deyhle MR. Divergent mechanisms regulate TLR4 expression on peripheral blood mononuclear cells following workload-matched exercise in normoxic and hypoxic environments. J Appl Physiol (1985). 2024;136(1):33-42
Special Interests:
I enjoy spending time with my wife and my 4 young kids. We like to be outside, visit parks, play sports and games. I also like wood working, playing classical guitar, and baking.