Research Interests:
My research is focused on understanding mechanisms of skeletal muscle plasticity-the ability to change and adapt to different stimuli and conditions. I have a keen interest in the role of the immune system in muscle plasticity and exercise adaptation. I have studied cytokines and immune cells in the context of a muscle damage-protective adaptation know as the repeated bout effect. As a post-doc at the University of Florida, I applied my interest in the immunology and skeletal muscle to study the role of tumor-derived cytokines and suppressive immune cells in the development and progression cancer-induced muscle wasting (cachexia). I am also interested in studying the unique physiological demands and strength and conditioning methods of non-traditional sports such as rock climbing.

Selected Publications:
Deyhle MR, Carlisle M, Sorensen JR, Hafen PS, Jesperson K, Ahmadi M, Hancock CR, Hyldahl RD. Accumulation of Skeletal Muscle T Cells and the Repeated Bout Effect in Rats. Medicine and Science in Sports and Exercise. 2020;52(6):1280-93. doi: 10.1249/mss.0000000000002256.

Judge SM, Deyhle MR, Neyroud D, Nosacka RL, D'Lugos AC, Cameron ME, Vohra RS, Smuder AJ, Roberts BM, Callaway CS, Underwood PW, Chrzanowski SM, Batra A, Murphy ME, Heaven JD, Walter GA, Trevino JG, Judge AR. MEF2c-dependent downregulation of Myocilin mediates cancer-induced muscle wasting and associates with cachexia in cancer patients. Cancer Research. 2020. doi: 10.1158/0008-5472.CAN-19-1558.

Callaway CS, Delitto AE, Patel R, Nosacka RL, D'Lugos AC, Delitto D, Deyhle MR, Trevino JG, Judge SM, Judge AR. IL-8 Released from Human Pancreatic Cancer and Tumor-Associated Stromal Cells Signals through a CXCR2-ERK1/2 Axis to Induce Muscle Atrophy. Cancers. 2019;11(12). doi: 10.3390/cancers11121863.

Sorensen JR, Kaluhiokalani JP, Hafen PS, Deyhle MR, Parcell AC, Hyldahl RD. An altered response in macrophage phenotype following damage in aged human skeletal muscle: implications for skeletal muscle repair. FASEB Journal. 2019;33(9):10353-68. doi: 10.1096/fj.201900519R.

Deyhle MR, Hafen PS, Parmley J, Preece CN, Robison M, Sorensen JR, Jackson B, Eggett DL, Hancock CR, Hyldahl RD. CXCL10 increases in human skeletal muscle following damage but is not necessary for muscle regeneration. Physiol Rep. 2018;6(8):e13689. doi: 10.14814/phy2.13689.

Deyhle MR, Hyldahl RD. The Role of T Lymphocytes in Skeletal Muscle Repair From Traumatic and Contraction-Induced Injury. Frontiers in Physiology. 2018;9:768. doi: 10.3389/fphys.2018.00768.
Special Interests:
I enjoy spending time with my wife, Anna, and my two kids Magnolia (4 years) and Joshua (2 years). We like to spend time outside, enjoying nature, visiting parks, playing sports and games. I also like to play the guitar and make music with Anna.