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Past Trainees
Irene Choi, Ph.D. 

Period of UNM-ARTN support: 08/01/03-05/31/05; mentors: Cunningham and Allan.  Irene’s PhD research demonstrated that moderate fetal alcohol exposure results in persistent deficits in adult hippocampal neurogenesis in mice.  Interestingly, these neurogenic deficits only become apparent when the adult fetal alcohol exposed mouse is behaviorally challenged.  For example, when exposed for several weeks to enriched living conditions, control mice display a 2-fold increase in hippocampal neurogenesis, whereas fetal alcohol exposed mice display no neurogenic response.  Further studies by Irene suggested that impaired neurogenesis is due to decreased survival and integration of new neurons in fetal alcohol exposed mice, and not due to a decrease in progenitor proliferation or in the size of progenitor pool within the subgranular zone.  Her dissertation research opened a new area of investigation for her research mentors and formed the basis for a NIAAA-funded R21.   Irene made progress quickly in her research and defended her dissertation work in May 2005. Her work was published in Alcohol. Clin. Exp. Res. (see list of manuscripts below). Irene was awarded a prestigious Fetal Alcohol Spectrum Disorder Study Group (FASDSG) Travel Stipend to present her work at the 2004 Annual Meeting of the FASDSG in Vancouver, Canada.  Irene was a NIAAA T32-funded postdoctoral fellow in the laboratory of Dr. Catherine Rivier at the Salk Institute, La Jolla, CA where she worked on Fetal Alcohol Exposure and Regulation of Hypothalamic Neuroendocrine Gene Expression.  She is currently a scientist at Nektar Therapeutics, San Francisco, CA.

Selected Publications:

Choi IY, Allan AM and Cunningham LA (2005) Moderate Fetal Alcohol Exposure Impairs the Neurogenic Response to an Enriched Environment in Adult Mice. Alcohol Clin Exp Res 29: 2053–2062.

 
Choi IY, Lee S, Rivier C. Novel role of adrenergic neurons in the brain stem in mediating the hypothalamic-pituitary axis hyperactivity caused by prenatal alcohol exposure.  Neuroscience. 2008 Aug 26;155(3):888-901.

 


Daniel Tanner, Ph.D.

Period of UNM-ARTN support: 08/08/03-06/30/05; mentor: Perrone-Bizzozero.  Dan’s initial project involved the characterization of the levels of expression and phosphorylation of GAP-43 in fetal alcohol exposed (FAE) rats under basal conditions and after being trained in a contextual fear conditioning (CFC) paradigm.  His results demonstrated that the levels of expression of GAP-43 were increased in FAE rats. Also, he showed that in correlation with the learning and memory deficits seen in FAE animals, these animals failed to activate the beta 2 and epsilon isoforms of PKC and to increase GAP-43 phosphorylation in the hippocampus after CFC. These studies were published in Alcohol. Clin. Exp. Res. (see Tanner et al, 2004, below). After completing these studies, Dan began working on how an increase in GAP-43 gene expression could lead to learning and memory deficits. For these studies, he took advantage of a HuD transgenic mouse generated in Dr. Perrone-Bizzozero’s laboratory that showed increased GAP-43 expression, decreased GAP-43 phosphorylation in the hippocampus and impaired hippocampal dependent learning and synaptic plasticity. The studies resulted in two additional publications (Bolognani et al., 2006 and 2007) and one manuscript in preparation (Tanner et al, see publications listing below). Dan finished his dissertation work in July of 2005. He was an NINDS T32-funded postdoctoral fellow in the laboratory of Margaret Mayer-Pröschel at the University of Rochester where he studied factors contributing to the differentiation of oligodendrocyte precursor cells.  He completed additional postdoctoral training at the University of Rochester under the support of a National MS Society Fellowship.  He is currently applying for faculty positions.

Selected Publications:

Tanner D.C., Githinji AW, Young EA, Meiri K, Savage DD, Perrone-Bizzozero NI. (2004)  Fetal alcohol exposure alters GAP-43 phosphorylation and protein kinase C responses to contextual fear conditioning in the hippocampus of adult rat offspring. Alcohol Clin Exp Res 28:113-22.

Bolognani, F., Tanner, D.C., Merhege, M., Jasmin, B. and Perrone-Bizzozero, N.I. (2006) In vivo post-transcriptional regulation of the GAP-43 mRNA by overexpression of the RNA-binding protein HuD. J. Neurochem, 96:790-801.

Bolognani F, Qiu S, Tanner DC, Paik J, Perrone-Bizzozero NI, Weeber EJ. (2007) Associative and spatial learning and memory deficits in transgenic mice overexpressing the RNA-binding protein HuD. Neurobiol Learn Mem. 87:635-43.

Bolognani F, Tanner DC, Nixon S, Okano HJ, Okano H, Perrone-Bizzozero NI.  Coordinated expression of HuD and GAP-43 in hippocampal dentate granule cells during developmental and adult plasticity. Neurochem Res. 2007 Dec;32(12):2142-51.

Tanner DC, Qiu S, Bolognani F, Partridge LD, Weeber EJ, Perrone-Bizzozero NI. Alterations in mossy fiber physiology and GAP-43 expression and function in transgenic mice overexpressing HuD. Hippocampus. 2008;18(8):814-23.

 


Sabrina Samudio-Ruiz, Ph.D. 

Period of UNM-ARTN support: 06/01/04-05/31/07; mentors: Caldwell and Allan.  Sabrina studied the neurochemical changes that are associated with moderate prenatal alcohol exposure in mice and that may underlie the learning and memory deficits that are observed in these animals.  Specifically, she investigated the effects of moderate prenatal alcohol exposure on N-methyl-D-aspartate (NMDA) receptor-mediated activation of extracellular signal-regulated kinase 2 (ERK2) in the hippocampal formation.  It was found that NMDAR-mediated stimulation of ERK2 is substantially decreased in mice exposed to alcohol in utero.  Sabrina was awarded a prestigious Fetal Alcohol Spectrum Disorder Study Group (FASDSG) Travel Stipend to present her work at the 2006 Annual Meeting of the FASDSG in Baltimore, MD.  Sabrina’s research was supported by an F31 Minority Predoctoral Fellowship from NIAAA.  She is currently part of the UNM-HSC Academic Science Education and Research Training (ASERT) program for postdoctoral fellows, which provides three years of support to individuals wishing to achieve excellence as both educators and research scientists in biology, bioengineering, and biomedical sciences.  Sabrina is currently doing toxicology research in the laboratory of Laurie Hudson, Ph.D. at the UNM-School of Pharmacy.

Selected Publications:

Caldwell KK, Sheema S, Paz RD, Samudio-Ruiz SL, Laughlin MH, Spence NE, Roehlk MJ, Alcon SN, Allan AM. Fetal alcohol spectrum disorder-associated depression: evidence for reductions in the levels of brain-derived neurotrophic factor in a mouse model. Pharmacol Biochem Behav. 2008 Oct;90(4):614-24.

Samudio-Ruiz SL, Allan AM, Valenzuela CF, Perrone-Bizzozero NI, Caldwell KK.  Prenatal ethanol exposure persistently impairs NMDA receptor-dependent activation of extracellular signal-regulated kinase in the mouse dentate gyrus. J Neurochem. 2009 Jun;109(5):1311-23. Epub 2009 Mar 20.

Samudio-Ruiz SL, Allan AM, Sheema S, Caldwell KK. Hippocampal N-methyl-D-aspartate receptor subunit expression profiles in a mouse model of prenatal alcohol exposure. Alcohol Clin Exp Res. 2010 Feb;34(2):342-53. Epub 2009 Nov 24.

 


Kate (Harms) Candelario, Ph.D.

Period of UNM-ARTN support: 06/01/05-05/31/06; mentor: Cunningham.  Kate’s research interests are in mechanisms of neuroprotection and cell death using in vitro models of injury.  Her projects include metalloproteinase regulation of neuronal cell death and the neurogenic response in stroke.  Although she had hoped to also study cell death and differentiation of neural stem cells isolated from adult fetal alcohol exposed mice, the methods for establishment of neural stem cells from adult animals were not fully worked out in the mentor laboratory until recently.  Thus, the steering committee for the training grant and her committee on studies advised her move off of the training grant in 2006 and focus on her studies in cerebral ischemia.  Kate’s research was supported by a predoctoral fellowship from the American Heart Association.  Kate defended her dissertation in August, 2010, completed postdoc training at UNM and recently moved to the University of Florida, Gainsville for additional postdoctoral training.

Selected Publications: 

Wetzel M, Li L, Harms KM, Roitbak T, Ventura PB, Rosenberg GA, Khokha R, Cunningham LA. Tissue inhibitor of metalloproteinases-3 facilitates Fas-mediated neuronal cell death following mild ischemia. Cell Death Differ. 2008 Jan;15(1):143-51. Epub 2007 Oct 26

Li L, Harms KM, Ventura PB, Lagace DC, Eisch AJ, Cunningham LA. Focal cerebral ischemia induces a multilineage cytogenic response from adult subventricular zone that is predominantly gliogenic. Glia. 2010 Oct;58(13):1610-9.

Harms KM, Li L, Cunningham LA. Murine neural stem/progenitor cells protect neurons against ischemia by HIF-1alpha-regulated VEGF signaling. PLoS One. 2010 Mar 22;5(3):e9767.

 


Jennifer Sanderson, Ph.D.

Period of UNM-ARTN support: 08/01/05-05/31/07; mentor: Valenzuela.  Jennifer studied the effects of ethanol on synaptic transmission in the developing rat neocortex.  Her studies rigorously tested the excessive inhibition hypothesis of fetal alcohol spectrum disorder.  This hypothesis states that ethanol damages the developing brain via a global mechanism that involves direct inhibition of NMDA receptors and potentiation of GABAA receptors.  Jennifer studies demonstrated that ethanol does not produce these effects in neocortical neurons.  These findings are inconsistent with the excessive inhibition model of ethanol-induced neurodegeneration, supporting the view that ethanol damages developing neurons via more complex mechanisms that vary among specific neuronal populations. Jennifer is currently a postdoctoral fellow in the laboratory of Dr. Mark Dell’acqua at the University of Colorado Denver.  She was supported by a T32 grant from NIAAA and is currently supported by a postdoctoral fellowship from the American Heart Association.

Selected Publications:

Guzowski JF, Miyashita T, Chawla MK, Sanderson J, Maes LI, Houston FP, Lipa P, McNaughton BL, Worley PF, Barnes CA. Recent behavioral history modifies coupling between cell activity and Arc gene transcription in hippocampal CA1 neurons. Proc Natl Acad Sci U S A. 2006 Jan 24;103(4):1077-82. Epub 2006 Jan 13.

 
Sanderson JL, Partridge LD, Valenzuela CF. Modulation of GABAergic and glutamatergic transmission by ethanol in the developing neocortex: an in vitro test of the excessive inhibition hypothesis of fetal alcohol spectrum disorder. Neuropharmacology. 2009 Feb;56(2):541-55

 
Bragin DE, Sanderson JL, Peterson S, Connor JA, Müller WS. Development of epileptiform excitability in the deep entorhinal cortex after status epilepticus. Eur J Neurosci. 2009 Aug;30(4):611-24.

Sanderson JL, Dell'Acqua ML. AKAP signaling complexes in regulation of excitatory synaptic plasticity.  Neuroscientist. 2011 Jun; 17: 321-36.


Vibhati Kulkarny, Ph.D.

Period of UNM-ARTN support: 08/01/2005-07/31/08; mentor: Perrone-Bizzozero.  Previous work by Dr. Perrone-Bizzozero’s lab demonstrated that the expression of the GAP-43 and BDNF genes is increased in post-mortem cerebellar tissue from patients with a history of alcohol abuse or dependence and Vibhati investigated the mechanisms by which alcohol produces these changes in gene expression using animal models. Vibhati found that alcohol vapor exposure increased the levels of GAP-43 and BDNF mRNAs in the hippocampus of P23 rats and that the same paradigm resulted in reduced expression of these genes in the cerebellum of the same animals. Her dissertation work involved imaging and genetic studies in the context of brain damage in alcoholics.  She is currently pursuing postdoctoral training at the VA Medical Center in Albuquerque.

Selected Publications:

Kulkarny, V.V., Wiest, N. E, .Marquez, C.M., Nixon, S., Valenzuela, C.F., and Perrone-Bizzozero, N .I. Opposite effects of acute binge-like ethanol exposure on GAP-43 and BDNF expression in the hippocampus versus the cerebellum of juvenile rats.  Alcohol.  2011 Aug; 45: 461-71.

 Kulkarny, V.V., C. Marquez; M. Rosenberg; C.R. Wolf; C.F. Valenzuela; D.D. Savage; N.I. Perrone-Bizzozero. Chronic ethanol exposure alters GAP-43 protein levels in the rat cerebellum.  RSA Meeting Chicago, 2007

 Kulkarny, V.V., C. Marquez; M. Rosenberg; C.F. Valenzuela; N.I. Perrone-Bizzozero. Alterations in GAP-43 gene expression in the rat cerebellum in a model of acute and chronic binge alcohol exposure. Society for Neurosciences, San Diego, 2007.

 


Richard Smrt, Ph.D.

Period of UNM-ARTN support: 1/1/2008-5/31/2008; mentor: Zhao. Richard obtained a minority supplement since June 1 2008.  Richard’s dissertation project tested the hypothesis that the expression of small RNAs modulates by Mecp2 and DNA methylation-mediated epigenetic mechanisms play a critical role in the maturation and survival of immature neurons in developing brains. Even though how Mecp2 regulates brain development is still unclear, current findings indicate that Mecp2 is a critical regulator for neuronal maturation that may be an alcohol effect in developing brains.  Richard defended his dissertation in September, 2010 and is currently pursuing postdoctoral training at the University of Arizona.

Selected Publications:

Smrt RD, Szulwach KE, Pfeiffer RL, Li X, Guo W, Pathania M, Teng ZQ, Luo Y, Peng J, Bordey A, Jin P, Zhao X. MicroRNA miR-137 regulates neuronal maturation by targeting ubiquitin ligase mind bomb-1. Stem Cells. 2010 Jun;28(6):1060-70.

Luo Y, Shan G, Guo W, Smrt RD, Johnson EB, Li X, Pfeiffer RL, Szulwach KE, Duan R, Barkho BZ, Li W, Liu C, Jin P, Zhao X. Fragile x mental retardation protein regulates proliferation and differentiation of adult neural stem/progenitor cells. PLoS Genet. 2010 Apr 8;6(4):e1000898.

Szulwach KE, Li X, Smrt RD, Li Y, Luo Y, Lin L, Santistevan NJ, Li W, Zhao X, Jin P.
Cross talk between microRNA and epigenetic regulation in adult neurogenesis. J Cell Biol. 2010 Apr 5;189(1):127-41.

Li X, Barkho BZ, Luo Y, Smrt RD, Santistevan NJ, Liu C, Kuwabara T, Gage FH, Zhao X. Epigenetic regulation of the stem cell mitogen Fgf-2 by Mbd1 in adult neural stem/progenitor cells. J Biol Chem. 2008 Oct 10;283(41):27644-52.

Zhao X, Pak C, Smrt RD, Jin P..Epigenetics and Neural developmental disorders: Washington DC, September 18 and 19, 2006. Epigenetics. 2007 Apr-Jun;2(2):126-34. Epub 2007 Apr 30.

Smrt RD, Eaves-Egenes J, Barkho BZ, Santistevan NJ, Zhao C, Aimone JB, Gage FH, Zhao X.  Mecp2 deficiency leads to delayed maturation and altered gene expression in hippocampal neurons. Neurobiol Dis. 2007 Jul;27(1):77-89.

Barkho BZ, Song H, Aimone JB, Smrt RD, Kuwabara T, Nakashima K, Gage FH, Zhao X. Identification of astrocyte-expressed factors that modulate neural stem/progenitor cell differentiation.  Stem Cells Dev. 2006 Jun;15(3):407-21

 


Michael Puglia, M.D/Ph.D.

Period of UNM-ARTN support: 08/01/2005-07/31/2008; mentor: Valenzuela.  Michael joined the UNM-MD/PhD program in 2004.  He completed the first portion of his MD studies and finished his PhD work.  He defended his PhD dissertation in December, 2009.  His research focused on the effects of 3rd trimester-equivalent alcohol exposure on synaptic transmission and plasticity in the hippocampus.  Michael is currently back in the MD portion of the curriculum.  He was currently supported by an F30 MD/PhD fellowship from NIAAA.  Michael completed with dual degree in May, 2012 and is currently an Anesthesiology Resident (Research Track) at Massachussets General Hospital in Boston.

Selected Publications:

Puglia MP, Valenzuela CF. AMPAR-mediated synaptic transmission in the CA1 hippocampal region of neonatal rats: unexpected resistance to repeated ethanol exposure. Alcohol. 43:619-25, 2009.

Puglia MP, Valenzuela CF. Ethanol Acutely Inhibits Ionotropic Glutamate Receptor-Mediated Responses and Long-Term Potentiation in the Developing CA1 Hippocampus. Alcohol Clin Exp Res. 34:594-606 2010.

Puglia MP, Valenzuela CF.  Repeated third trimester-equivalent ethanol exposure inhibits long-term potentiation in the hippocampal CA1 region of neonatal rats.  Alcohol. 44:283-90, 2010.

Valenzuela CF, Puglia MP, Zucca S.  Neurotransmitter Systems in Fetal Alcohol Spectrum Disorder.  Alcohol Research and Health.  34, 106-120, 2011.

 


Travis Johnson, M.Sc.

Period of UNM-ARTN support: 08/01/2007-02/28/2009; mentors: Hamilton and Savage. Travis’ project investigated the effects of moderate prenatal alcohol exposure on signal transmission, field potentials, and single unit physiology in orbitofrontal cortex (OFC). Traves is currently pursuing graduate work in Religious Studies.

Selected Publications:

Hamilton, D. A., Akers, K. G., Johnson, T. E., Rice, J. P., Candelaria, F. T., Sutherland, R. J., Weisend, M. P., & Redhead, E. S. (2008). The relative influence of place and direction in the Morris water task. Journal of Experimental Psychology: Animal Behavior Processes, 34, 31-53.

Hamilton, D. A., Akers, K. G., Johnson, T. E., Rice, J. P., Candelaria, F. T., & Redhead, E.S. Evidence for a shift from place navigation to directional responding in one variant of the Morris water task. J Exp Psychol: Anim Behav Process. 2009 Apr;35(2):271-8

 
Hamilton, D.A., Johnson, T.E., Redhead, E.S., & Verney, S.P. Control of human and rodent navigation by room and apparatus cues. Behav Processes. 2009 Jun;81(2):154-69.

 
Akers, K. G., Candelaria, F. T., Rice, J. P., Johnson, T. E., & Hamilton, D. A. Delayed development of place navigation compared to directional responding in preweanling rats. Behav Neurosci. 2009 Apr;123(2):267-75

 
Akers KG, Candelaria-Cook FT, Rice JP, Johnson TE, Hamilton DA.Cued platform training reveals early development of directional responding among preweanling rats in the morris water task. Dev Psychobiol. 2010 Aug 4. [Epub ahead of print] PMID: 20687138

 
Hamilton DA, Akers KG, Rice JP, Johnson TE, Candelaria-Cook FT, Maes LI, Rosenberg M, Valenzuela CF, Savage DD. Prenatal exposure to moderate levels of ethanol alters social behavior in adult rats: relationship to structural plasticity and immediate early gene expression in frontal cortex. Behav Brain Res. 2010 Mar 5;207(2):290-304

 


Shirley Smith, B.Sc.

Period of UNM-ARTN support: 08/01/2008-07/31/10; mentor: Hutchison.  Shirley is a PhD student in the Psychology Department. She is doing research related to alcoholism treatment in adolescent and adult populations.  In the latter, she is studying the effect of olanzapine on craving and alcohol dependence.  Her current work is focused on integrating scientific research with clinical interventions (primarily Motivational Enhancement Therapy).  She is studying the relationship between genotype (BDNF specifically), neural structure (through magnetic resonance imaging) and drinking behaviors among adolescents.

Selected Publications:

Feldstein-Ewing, SW., Smith, SM. (In Press). Serving Dually Diagnosed Youth in the Juvenile Justice System. Book chapter in Handbook of Juvenile Forensic Psychology and Psychiatry.

Jung RE, Segall JM, Jeremy Bockholt H, Flores RA, Smith SM, Chavez RS, Haier RJ. 2009. Neuroanatomy of Creativity. Human Brain Mapping. 2010 Mar;31(3):398-409 (Epub ahead of print). PMCID: PMC2826582

 
Jung RE, Gasparovic C, Chavez RS, Flores RA, Smith SM, Caprihan A, Yeo RA. 2009. Biochemical support for the “threshold” theory of creativity: a magnetic resonance spectroscopy study. Journal of Neuroscience. 29(16): 5319-25. PMCID: PMC2755552

 


Miranda Staples, B.Sc.

Period of UNM-ARTN support: 08/01/2008-07/30/11; mentor: Savage.  Miranda is a PhD student in the Biomedical Sciences Graduate Program.  She has trained in a variety of experimental procedures including our prenatal ethanol exposure paradigm, one-trial contextual fear conditioning and Morris Water Tasks, and both RT-PCR and western blotting procedures on placental tissues from ethanol-consuming rat dams.  Over the past year she has devoted considerable time and effort in refining a maternal stress paradigm, using predator scent as a stressor, and measuring serum corticosterone levels in exposed female rats.  Her dissertation project will focus on the interactive effects of maternal ethanol consumption and maternal stress on trace conditioning and trace-conditioning dependent changes in Arc expression and dentate granule cell dendritic morphology.  Miranda is currently supported by an F31 predoctoral fellowship from NIAAA.

 
Selected Publications:

 
Rosenberg, M.J., Wolff, C.R., El-Emawy, A., Staples, M.C., Perrone-Bizzozero, N.I. and Savage, D.D.:  Effects of moderate drinking during pregnancy on placental gene expression.  Alcohol (2010). Nov-Dec;44(7-8):673-90.

 
Savage, D.D., Rosenberg, M.J., Wolff, C.R., Akers, K.G., El-Emawy, A.A., Staples, M.C., Varaschin, R.K., Wright, C.A., Seidel, J.L., Caldwell, K.K., and Hamilton, D.A.:  Effects of a novel cognition-enhancing agent on fetal ethanol-induced learning deficits.  Alcoholism: Clin. Exp. Res. 2010 Oct;34(10):1793-802.


Megan Brady, Ph.D.

Period of UNM-ARTN support: 08/01/2008-06/30/2011; mentor: Caldwell. Megan is a PhD student in the Biomedical Sciences Graduate Program and her project aims to identify potential mechanisms underlying synaptic plasticity and cognitive functioning impairments that are associated with prenatal alcohol exposure, focusing on the effects of prenatal alcohol exposure on the structure and function of N-methyl-D-aspartate (NMDA) receptors in the hippocampal dentate gyrus.  Previous studies have indicated that prenatal alcohol exposure may exert its effects on NMDA neurotransmission via effects on the subcellular localization of NMDA receptors.  Megan's project will include a series of analyses of NMDA receptor subcellular localization, protein-protein interactions and receptor-channel function.   Megan is was supported by an F31 predoctoral fellowship from NIAAA.  She defended her dissertation in the Spring of 2012 and is currently a postdoctoral fellow in the Jacob laboratory at U. of Pittsburgh.

 

Selected Publications:

Brady ML, Allan AM, Caldwell KK (2012)  A limited access mouse model of prenatal alcohol exposure that displays long-lasting deficits in hippocampal-dependent learning and memory.  Alcohol Clin Exp Res. 36: 457-466. PMC Journal - In Process

Brady ML, Diaz MR, Everett JC, Valenzuela CF, Caldwell, KK. Moderate prenatal alcohol exposure reduces plasticity and alters NMDA receptor subunit composition in the dentate gyrus.  J. Neuroscience.  Submitted.


James Rice, M.Sc. 

Period of UNM-ARTN support: 08/01/2009-07/31/2012; mentor: Hamilton. Jim’s projects include the effect of moderate prenatal alcohol exposure on reversal learning and social behavior in adult rats, and related neurobiological processes in the frontal cortex. Jim is also investigating the effect of moderate prenatal ethanol exposure on voluntary consumption of alcohol in adulthood and related reward circuitry in the striatum.  Jim investigated the effects of moderate fetal ethanol exposure on the dendritic morphology of medium spiny neurons in several regions of the striatum. Relative to saccharin controls, robust reductions in dendritic length and branching, but not spine density, were observed in the shell of the nucleus accumbens in fetal ethanol-exposed rats. No significant prenatal ethanol effects were found in the other regions of the striatum. These findings suggest that exposure to moderate levels of ethanol in utero can have profound effects on brain regions related to reward processing and provide possible clues relevant to understanding increased self-administration of drugs of abuse in animals exposed to ethanol during brain development. Jim has advanced to candidacy and submitted a revised F31 NRSA application in April, 2012 that obtained a terrific score (i.e., a 20).  Jim will present a poster at the RSA meeting in San Francisco in June, 2012.  Jim’s data contributed to the success of Dr. Hamilton’s current R01 grant entitled: “Fetal ethanol-induced deficits in agranular insular cortex function”.

Selected Publications:

Akers, K.G., Candelaria-Cook, F.T., Rice, J.P., Johnson, T.E., Hamilton, D.A.  Cued platform training reveals early deveopment of directional responding among preweanling rats in the Morris water task.  Dev. Pscyhobiol. 2011 Jan; 53(1): 1-12.

Hamilton, D.A., Candelaria-Cook, F.T., Akers, K.G., Rice, J.P., Maes, L.I., Rosenberg, M., Valenzuela, C.F., & Savage, D.D. (2010). Patterns of social-experience-related c-fos and Arc expression in the frontal cortices of rats exposed to saccharin or moderate levels of ethanol during prenatal brain development. Behavioural Brain Research, 2010 Dec 6; 214(1):66-74. PMCID: 20570698

Hamilton, D.A., Akers, K.G., Rice, J.P., Johnson, T.E., Candelaria-Cook, F.T., Maes, L.I., Rosenberg, M., Valenzuela, C.F., & Savage, D.D. (2010). Prenatal exposure to moderate levels of ethanol alters social behavior in adult rats: Relationship to structural plasticity and immediate early gene expression in frontal cortex. Behavioural Brain Research, 2010 Mar 5;207(2):290-304. Epub 2009 Oct 21. PMCID: PMC2815207 [Available on 2011/3/5]

Hamilton, D.A., Akers, K.G., Johnson, T.E., Rice, J.P., Candelaria, F.T., & Redhead, E.S. (2009). Evidence for a shift from place navigation to directional responding in one variant of the Morris water task. Journal of Experimental Psychology: Animal Behavior Processes, 2009 Apr;35(2):271-8. PMCID: PMC Journal – In Process

Akers, K.G., Candelaria, F.T., Rice, J.P., Johnson, T.E., & Hamilton, D.A. (2009). Delayed development of place navigation compared to directional responding in preweanling rats. Behavioral Neuroscience, Apr;123(2):267-75. PMCID: PMC Journal – In Process

Rice JP, Suggs LE, Lusk AV, Parker MO, Candelaria-Cook FT, Akers KG, Savage DD, Hamilton DA. (2012) Effects of exposure to moderate levels of ethanol during prenatal brain development on dendritic length, branching, and spine density in the nucleus accumbens and dorsal striatum of adult rats.  Alcohol.  46:577-84.


Carrie Wright, B.Sc.

Carrie Wright is a fourth year BSGP student.  She joined the laboratory of Dr. Lee Anna Cunningham in Fall, 2010. Carrie’s dissertation project was focused on elucidating mechanism by which prenatal alcohol impairs enrichment-mediated neurogenesis in adult hippocampus.  Carrie presented a poster at the RSA-2011 meeting in Atlanta.  Carrie has joined the laboratory of Dr. Perrone-Bizzozero where she is working on a bioinformatics project related to schizophrenia research.

Publications:

Savage, D.D., Rosenberg, M.J., Wolff, C.R., Akers, K.G., El-Emawy, A.A., Staples, M.C., Varaschin, R.K., Wright, C.A., Seidel, J.L., Caldwell, K.K., and Hamilton, D.A.:  Effects of a novel cognition-enhancing agent on fetal ethanol-induced learning deficits.  Alcoholism: Clin. Exp. Res. 2010 Oct;34(10):1793-802.


Christina Tyler, B.Sc. 


Period of UNM-ARTN support: 08/01/2011-07/31/13; mentor: Allan.  Christina is a BSGP student.  She joined the laboratory of Dr. Allan in the fall of 2011.  Christina graduated from Fort Lewis College in 2006 with a B.Sc in Chemistry, a minor in Physics, and a license to teach secondary science.  Christina’s dissertation project focuses on epigenetic regulation of adult neurogenesis and FASD.  

Publications:

Caldwell KK, Goggin SL, Tyler CR, Allan AM. Prenatal Alcohol Exposure Is Associated with Altered Subcellular Distribution of Glucocorticoid and Mineralocorticoid Receptors in the Adolescent Mouse Hippocampal Formation.  Alcohol Clin Exp Res. 2013 Aug 19. doi: 10.1111/acer.12236. [Epub ahead of print]


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