| Associate Professor Department of Neurosciences |
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Research
Interests:
Main interests concern the development of the nervous system, including periods from the earliest phases of the morphological development of the brain and spinal cord to periods of neuronal differentiation and migration. Other major interests involve the characterization of factors that regulate the development of neurotransmitter systems and the formation of their early connections in the nervous system. Recent work has also involved the use of the embryonic spinal cord as a model to study spinal cord regeneration and potential changes in neuronal function in regions of the spinal cord isolated localized injury. Currently, Dr. Milligan and I am are collaborating on studies of neural stem cells within the spinal cord and examining their response to peripheral nerve injury. These cells may provide a unique source of newly generated neurons and glia that can be utilized to introduce genetic therapies for treating chronic neuropathologic pain conditions.
Selected Publications:
Wallace, J.A. and J.M. Lauder (1983) The prenatal ontogeny of central serotonergic systems in the rat: An immunocytochemical study. Brain Res. Bull. 10: 459-497.
Wallace, J.A. (l985) An immunocytochemical study of the development of central serotoninergic neurons in the chick embryo. J. Comp. Neurol. 236: 443-453.
Wallace, J.A., R.M. Mondragon, P.C. Allgood, T.J. Hoffman and R. R. Maez (1987) Two populations of tyrosine hydroxylase-positive cells occur in the spinal cord of the chick embryo. Neurosci. Letts., 83:253-258.
Wallace, J.A. (1988) Neurotransmitter Substances in Early Embryogenesis. In: Amino Acid Availability and Brain Function in Health and Disease, NATO ASI Series, G. Huether, ed., Springer-Verlag, Berlin, pp. 231-240.
Wallace, J.A. and Lauder, J.A. (1992) Development of the serotonergic system in rat and chick embryos. In: Handbook of Chemical Neuroanatomy, Vol. 10: Ontogeny of Transmitters and Peptides in the CNS, edited by A. Bjorklund, T. Hokfelt and M. Tohyama, Elsevier Sciences Publishers B.V., Amsterdam, pp. 619-646.
Wallace, J.A., A.A. Romero, A.M. Gabaldon, V. A. Roe, S.L. Saavedra and J. Lobner (1996) Tyrosine hydroxylase-containing neurons in the spinal cord of the chicken. I. Development and analysis of catecholamine synthesis capabilities. Cell. and Molec. Neurobiology 16(5):625-648.
Rosenberg, G.A., Cunningham, L.A., Wallace, J.A., Alexander, S, Estrada, E.Y., Grossette, M., Razahgi, A., Miller, K. and Gearing, A. (2001) Immunohistochemistry of matrix metalloproteinases in reperfusion injury to rat brain: Activation of MMP-9 linked to stromelysin-1 and microglia in cell cultures. Brain Res. 893:104-112.
Gasparovic, C., Rosenberg, G.A., Wallace, J.A., Estrada, E.Y., Roberts, K., Pastuszyn, A. and Graham, G.D. (2001) Increases in magnetic resonance lipid signals in brain after experimental stroke correlate with neutral lipid accumulation. Neurosci. Letts. 301:87-90.
Mun-Bryce, S., Lukes, A., Wallace, J.A., Lukes-Marx, M., and Rosenberg, G. (2002) Stromelysin-1 and gelatinase A are upregulated before TNF-? in LPS-stimulated neuroinflammation. Brain Res. 933: 42-49.
Wallace, J.A., Alexander, S., Estrada, E.Y., Hines, C., Cunningham, L. and Rosenberg, G.A. (2002) Tissue Inhibitor to metalloproteinase-3 (TIMP-3) is associated with neuronal death in reperfusion injury. J. Cerebral Blood Flow & Metab.; 22:1303-1310.
Appenzeller, O., Cornelissen, G., Halberg, F., Wallace, J.A. and Costa, M.A. (2002) Biological rhythms and behavior; Then and now. Med. Science Monitor., 8(9):26-30.
Rosenberg, G.A., Wallace, J.A., Wetzel, M. and Cunningham, L.A. (2002) Tissue inhibitor of metalloproteinase-3 facilitates neuronal death. (Book Chapter submitted, Marburg Conference).
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