Vincent P. Clark

Associate Professor
Email: vclark@unm.edu
Office: Logan 118
Phone: 505-277-2223

Research Interests
We use a variety of tools to investigate the relationship between the mind and brain. In association with The MIND Institute (http://www.mrn.org) we employ structural and functional magnetic resonance imaging (fMRI), magnetoencephalography (MEG), event-related potentials (ERPs) and other methods to examine human brain structure and function. Using these tools, we are investigating the basic organizational principles of perception, learning, memory, attention and language in healthy individuals. We also use these methods to examine the neural basis of psychiatric disorders such as drug and gambling addiction, psychopathy and schizophrenia. We are developing new methods of data analysis for combining data from different imaging techniques in order to gain fundamentally new information on human brain structure and function, called multimodal imaging, and are using this and other methods to expand the boundaries of brain imaging techniques. Our most recent work uses transcranial direct current stimulation (tDCS) to increase learning and memory in healthy subjects. Brain stimulation may lead to a variety of innovations in classroom education and professional training, along with new methods for treating clinical disorders. Dr. Clark is also serving as director of the new Clinical Neuroscience Center being built in Logan Hall, which will include TMS and tDCS laboratories, along with multiple high-density EEG systems and a data storage and analysis core.

List of Recent Publications

• Clark, V.P., Coffman, B.A., Mayer, A.R., Weisend, M.P., Lane, T.D.R., Calhoun, V.D., Raybourn, E.M., Garcia, C.M., Wassermann, E.M. (2010) TDCS guided using fMRI significantly accelerates learning to identify concealed objects. NeuroImage, In press. [FULL TEXT]
• E.A. Allen, E.B. Erhardt, E. Damaraju, W. Gruner, J.M. Segall, R.F. Silva, M. Havlicek, S. Rachakonda, J. Fries, R. Kalyanam, A.M. Michael, A. Caprihan, J.A. Turner, T. Eichele, S. Adelsheim, A. Bryan, J. Bustillo, V.P. Clark, S. Feldstein Ewing, F. Filbey, C. Ford, K. Hutchison, R.E. Jung, K.A. Kiehl, P. Kodituwakku, Y. Komesu, A.R. Mayer, G. Pearlson, J. Phillips, J. Sadek, M. Stevens, U. Teuscher, R.J. Thoma, V.D. Calhoun. (2010) A baseline for the multivariate comparison of resting state networks. Frontiers in Systems Neuroscience, In press.
• Abbott, C., Juarez, M., White, T., Gollub, R.L., Pearlson, G.D., Bustillo, J. Lauriello, J., Ho, B.C., Bockholt, H. J., Clark, V.P., Magnotta, V., Calhoun, V.D. Antipsychotic dose and diminished neural modulation: A multi-site fMRI study. Progress in Neuro-Psychopharmacology & Biological Psychiatry, In press. [ABSTRACT]
• Kim, D.I, Sui, J., Rachakonda, S., White, T., Manoach, D. S., Clark, V. P., Ho, B. C., Schulz, S. C. and Calhoun, V. D. (2010) Identification of imaging biomarkers in schizophrenia: A coefficient-constrained independent component analysis of the Mind multi-site schizophrenia study. Journal of NeuroInformatics, In Press. [ABSTRACT]
• Ehrlich, S., Morrow, E.E., Roffman, J.L., Wallace, S.R., Naylor, M., Bockholt, H.J., Lundquist, A., Yendiki, A., Ho, B.C., White, T., Manoach, D., Clark, V.P., Calhoun, V.D., Gollub, R.L., Holt, D.J. (2010) The COMT Val108/g158Met polymorphism and medial temporal lobe volumetry in patients with schizophrenia and healthy adults. NeuroImage, 53(3): 992-1000. [ABSTRACT]
• Michael, A.M., Baum, S.A., Demirci, O., Segall, J., Jung, R., Clark, V.P., Bockholt, H.J., Gollub, R.L., Roffman, J.L., Ho, B.C., Andreasen, N.C., Lim, K.O., White, T., Schulz, S.C., Calhoun, V.D. (2010) Does function follow form?: Methods to fuse structural and functional brain images show decreased linkage in schizophrenia. NeuroImage, 49(3):2626-2637. [ABSTRACT]
• White, T., Magnotta, V.A., Bockholt, H.J., Williams, S., Gollub, R.L., Mueller, B.A., Ho, B.C., Jung, R., Clark, V.P., Lauriello, J., Bustillo, J.R., Schulz, S.C., Andreasen, N.C., Calhoun, V.D., Lim. K.O. (2009) Global white matter abnormalities in schizophrenia: a multisite diffusion tensor imaging study. Schizophrenia Bulletin, 35:204-205. [ABSTRACT]
• Kim, D.I., Manoach, D.S., Mathalon, D.H., Turner, J.A., Mannell, M., Brown, G.G., Ford, J.M., Gollub, R.L., White, T., Wible, C., Belger, A., Bockholt, H.J., Clark, V.P., Lauriello, J., O'Leary, D., Mueller, B.A., Lim, K.O., Andreasen, N., Potkin, S.G., Calhoun, V.D. Dysregulation of working memory and default-mode networks in schizophrenia using independent component analysis, an fBIRN and MCIC study. Human Brain Mapping, 30(11):3795-3811. [ABSTRACT]
• Demirci, O., Stevens, M.C., Andreasen, N.C., Michael, A., Liu, J., White, T., Pearlson, G.D., Clark, V.P., Calhoun, V.D. (2009) Investigation of relationships between fMRI brain networks in the spectral domain using ICA and Granger causality reveals distinct differences between schizophrenia patients and healthy controls. NeuroImage, 46(2):419-431. [ABSTRACT]
• Sui, J., Adali, T., Pearlson, G.D., Clark, VP, Calhoun, VD. (2009) A method for accurate group difference detection by constraining the mixing coefficients in an ICA framework. Human Brain Mapping, 30(9): 2953-2970. [ABSTRACT]
• Burge, J., Lane, T., Link, H., Qiu, S., Clark, V.P. (2009) Discrete dynamic Bayesian network analysis of fMRI data. Human Brain Mapping, 30(1):122-137. [ABSTRACT]
• Segall, J.M., Turner, J.A., van Erp, T.G.M., White, T., Bockholt, H.J., Gollub, R.L., Ho, B.C., Magnotta, V., Jung, R.E., McCarley, R.W., Schulz, S.C., Lauriello, J., Clark, V.P., Voyvodic, J.T., Diaz, M.T., Calhoun V.D. (2009) Voxel-based morphometric multi-site collaborative study on schizophrenia. Schizophrenia Bulletin, 35(1):82-95. [ABSTRACT]
• Mayer, A.R., Franco, A., Hanlon, F.M., Thoma, R.J., Clark, V.P., Canive, J.M. (2009) The neural networks underlying auditory sensory gating. NeuroImage, 44(1):182-189. [ABSTRACT]
• Leyba, L., Mayer, A.R., Gollub, R.L., Andreasen, N.C, Clark, V.P. (2008) Smoking status as a potential confound in the BOLD response of patients with schizophrenia. Schizophrenia Research, 104(1):79-84. [ABSTRACT]
• Roffman, J.L., Gollub, R.L., Calhoun, V.D., Wassink, T.H., Weiss, A.P., Ho, B.C., White, T., Clark, V.P., Fries, J., Andreasen, N.C., Goff, D.C., Manoach, D.S. (2008) MTHFR 677C-T genotype disrupts prefrontal function in schizophrenia through an interaction with COMT 158Val-Met. PNAS, 105(45):17573-17578. [ABSTRACT]
• Demirci, O., Clark, V.P., Calhoun, V.D. (2008) A projection pursuit application to detect schizophrenia using fMRI data. NeuroImage, 39(4):1774-1782.
• Demirci, O., Clark, V.P., Magnotta, V.A., Andreasen, N.C., Lauriello, J., Kiehl, K.A., Pearlson, G.D., Calhoun, V.D. (2008) A review of challenges in the use of fMRI for disease classification / characterization and a projection pursuit application from multi-site fMRI schizophrenia study. Brain Imaging and Behavior, 2(3):207-226. [ABSTRACT]
• Whalen, D., Benson, R. Richardson, M., Swainson, B., Clark, V.P., Lai, S., Mencl, W., Fulbright, R., Constable, R.T., Liberman, A. (2006) Differentiation of speech and non-speech processing within primary auditory cortex. Journal of the Acoustical Society of America, 119(1), 575-581.
• Clark, V.P. (2005) Attention. In: N.J. Salkind, Neil J. (Ed.). Encyclopedia of Human Development. Sage Publications. Thousand Oaks, CA, pp. 133-136.
• Clark, V.P. (2005) Structural and Functional Brain Imaging. In: N.J. Salkind, Neil J. (Ed.). Encyclopedia of Human Development. Sage Publications. Thousand Oaks, CA, pp.1232-1235.
• Clark, V.P. (2005) Huntington's Chorea. In: N.J. Salkind, Neil J. (Ed.). Encyclopedia of Human Development. Sage Publications. Thousand Oaks, CA, pp. 660-661.
• Stevens, M.C., Clark, V.P., Prestwood, K.M. (2005). Low-dose estradiol alters brain activity. Psychiatry Research: Neuroimaging, 139(3):199-217.
• Clark, V.P. (2005). Attention. In: N.J. Salkind, Neil J. (Ed.). Encyclopedia of Human Development. Sage Publications. Thousand Oaks, CA (In press).
• Burge, J., Clark, V. P., Lane, T., Link, H., Qiu. S. (2004). Bayesian classification of fMRI data: Evidence for altered neural networks in dementia. Technical Report TR-CS-2004-28, University of New Mexico, Albuquerque, NM.
• Clark, V. P. (2002). Orthogonal polynomial regression for the detection of response variability in event-related MRI. NeuroImage, 17, 344-363. [ABSTRACT]
• Clark, V. P., Lai, S., Deckel, A. W. (2002). Altered functional MRI responses in Huntington's disease. Neuroreport, 13(5), 703-706.
• Clark, V. P., Fannon, S., Lai, S., Benson, R. (2001). Paradigm-dependent modulation of event-related fMRI activity evoked by the oddball task. Human Brain Mapping, 14(2), 116-127.  [FULL TEXT]
• Benson, R. R., Whalen, D. H., Richardson, M., Swainson, B., Clark, V. P., Lai, S., Liberman, A. M. (2001). Parametrically dissociating speech and non-speech perception in the brain using fMRI. Brain and Language, 78, 364-396. [FULL TEXT]
• Clark, V. P., Fannon, S., Lai, S., Benson, R., Bauer, L. (2000). Responses to rare visual target and distractor stimuli using event-related fMRI. Journal of Neurophysiology, 83(5), 3133-3139.  [FULL TEXT]
• Deckel, A. W., Weiner, R., Szigeti, D. Clark, V. P., and Vento, J. (2000). Altered patterns of regional cerebral blood flow in patients with Huntington's disease: A SPECT study during rest and cognitive or motor activation. Journal of Nuclear Medicine, 41, 773-780. [ABSTRACT]
• Haxby, J. V., Ungerleider, L. G., Clark, V. P., Schouten, J. L., Hoffman, E. A., Martin, A. (1999). The effect of face inversion on activity in human neural systems for face and object perception. Neuron, 22, 189-199. [ABSTRACT]
• Clark, V. P., Maisog, J. Ma., Haxby, J. V. (1998). An fMRI study of face perception and memory using random stimulus sequences. Journal of Neurophysiology, 79, 3257-3265. [FULL TEXT]
• Bavelier, D., Corina, D., Jezzard, P., Clark, V., Karni, A., Lalwani, A., Rauschecker, J. P., Braun, A., Turner, R and Neville, H. J. (1998). Hemispheric specialization for English and ASL: Left invariance - right variability. Neuroreport, 9, 1537-1542.
• Haxby, J. V., Courtney, S. C., Clark, V. P. (1998). Functional magnetic resonance imaging and the study of attention. In R. Parasuraman (Ed.). The Attentive Brain. MIT Press: Cambridge, pp. 123-142.
• Neville, H. J., Bavelier, D., Corina, D., Rauschecker, J., Karni, A., Lalwani, A., Braun, A., Clark, V. P., Jezzard, P., Turner, R. (1998). Cerebral organization for language in deaf and hearing subjects: Biological constraints and effects of experience. Proceedings of the National Academy of Sciences of the United States of America, 95(3), 922-929. [FULL TEXT]
• Clark, V. P., Parasuraman, R., Keil, K., Kulansky, R., Fannon, S., Maisog, J. Ma., Ungerleider, L., Haxby, J. V. (1997). Selective attention to face identity and color studied with fMRI. Human Brain Mapping, 5(4), 293-297. [FULL TEXT]
• Haxby, J. V., Clark, V. P., Courtney, S. C. (1997). Distributed hierarchical neural systems for visual memory in human cortex. In: B. Hyman, C. Duyckaerts, Y. Christen (Eds.). Connections, Cognition, and Alzheimer's Disease. Springer, Berlin, pp. 167-180.
• Petit, L., Clark, V. P., Ingeholm, J., Haxby, J. V. (1997). Dissociation of saccade-related and pursuit-related activation in human frontal eye fields as revealed by fMRI. Journal of Neurophysiology, 77, 3386-3390. [FULL TEXT]
• Bavelier, D., Corina, D., Jezzard, P., Padmanabhan, S., Clark, V. P., Karni, A., Prinster, A., Braun, A., Lalwani, A., Rauschecker, J., Turner, R., Neville, H. (1997). Sentence reading: A functional MRI study at 4 tesla. Journal of Cognitive Neuroscience, 9, 664-686.
• Clark, V.P., Keil, K., Maisog, J.Ma., Courtney, S.M., Ungerleider, L.G., and Haxby, J.V. (1996) Functional magnetic resonance imaging of human visual cortex during face matching: A comparison with positron emission tomography. NeuroImage, 4(1): 1-15. Clark, V.P. and Hillyard, S.A. (1996) Spatial selective attention affects early extrastriate but not striate components of the visual evoked potential. Journal of Cognitive Neuroscience, 8(5): 387-402. [FULL TEXT]
• Clark, V.P., Fan, S. and Hillyard, S.A. (1995) Identification of early visual evoked potential generators by retinotopic and topographic analyses. Human Brain Mapping, 2: 170-187. [FULL TEXT]
• Clark, V.P., Courchesne, E., and Grafe, M. (1992) In vivo myeloarchitectonic analysis of human striate and extrastriate cortex using magnetic resonance imaging. Cerebral Cortex, 2: 417-424. [ABSTRACT]