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INTRODUCTION
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Recent neuropathological investigation of brain injury has focused on selective
neuronal damage, particularly of the hippocampus following transient forebrain
hypoxia/ischemia. Following a focal impact trauma to the rat sensorimotor
cortex (SMCX) there is a cascade of neuropathological sequalae (3,6). These
events result in a focal contusion of SMCX, a slow developing panecrotic
cyst near the impact and selective neuronal injury in subcortical areas
(6) There are few studies of neuronal survival at the site of focal traumatic
brain injury (TBI) the subject of this study . We hypothesize two possible
mechanisms for the panecrosis at the impact site:
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phagocytosis of neurons injured by the mechanical forces and/or "Secondary
Neurological Injury" occurring in 6-8 hours after injury
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"Tertiary Neuronal Injury", neuronal death occurring days to weeks after
stroke or TBI
Poster Title Page | Methods
| Results | Conclusion