| Special Topic: Negative feedback loop NOT working with a person with Type 2 diabetes |
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| Class, make sure you can DRAW or WRITE out this graphic completely. This clearly shows the negative feedback loop not working with a person with Type 2 diabetes. |
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| With insulin resistance, insulin is not reacting effectively with the insulin protein receptors on the muscle. Importantly, exercise independently activates the GLUT4 shuttle proteins to intake glucose. |
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| Note that during exercise with untrained and trained persons that insulin levels drop. The contracting muscles activate the GLUT4 shuttle proteins (thus, increasing the transport of glucose into the contracting muscle cells). Also, epinephrine and norepinephrine inhibit insulin release from the pancreas. |
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