Publications (72 total):


After joining UNM (independent research work, 8/2003-present, *as corresponding author):


  1. Wang, J.; Li, H.; Zu, L.-S.; Jiang, W.; Xie, H.-X.; Duan, W.-H.; Wang, W.* “Enantioselective Organocatalytic Conjugate Additions to Enones” J. Am. Chem. Soc., 2006, 128, in press.


  1. Wang, J.; Li, H.; Zu, L.-S.; Wang, W.* “Organocatalytic Michael Addition of N-Heterocycles to Nitroolefins” Synthesis, 2007, invited to contribute to Practical Synthetic Procedures (PDS-Articles in Synthesis.


  1. Zu, L.-S.; Wang, J.; Li, H.; Yu, X-H.; Wang, W.* “A Recyclable Fluorous (S)-Pyrrolidine Sulfonamide Promoted Direct, Highly Enantioselective Michael Addition of Ketones and Aldehydes to Nitroolefins in Water” Org. Lett., 2006, 8, 3077-3079. (This work has been highlighted in http://www.organic-chemistry.org/abstracts/lit1/320.shtm).


  1. Liu, S.-Y.; Fan, Y.-P.; Peng, X.-X.; Wang, W.;* Hua, W.-Y.; Akber, H.; Liao, L.-X.* “A Concise and Enantioselective Approach to the Total Synthesis of (-)-Lasubine I” Tetrahedron Lett., 2006, in press.


  1. Wang, J.; Heikkinen, L. D.; Li, H.; Zu, L.-S.; Jiang, W.; Wang, W.* “Quinine-Catalyzed Enantioselective Michael Addition of Diphenyl Phosphite to Nitroolefins: Synthesis of Chiral Precursors of a-Substituted b-Amino Phosphonates” Submitted to Adv. Synth. Catal..


  1. Wang, W.;* Li, H.; Wang, J.; Zu, L.-S.; “Enantioselective Organocatalytic Tandem Michael-Aldol Reactions: One-Pot Synthesis of Chiral Thiochromenes” J. Am. Chem. Soc., 2006, 128, 10354-10355.


  1. Wang, J.; Li, H.; Zu, L.; Jiang, W.; Wang, W.* “Organocatalytic, Enantioselective Conjugate Addition of Nitroalkanes to Nitroolefins” Adv. Synth. Catal., 2006, in press.


  1. Wang, J.; Li, H.; Zu, L.-S.; Wang, W.* “Enantioselective Organocatalytic Michael Addition Reactions between N-Heterocycles and Nitroolefins” Org. Lett., 2006, 8, 1391-1394.


  1. Wang, J.; Li, H.; Zu, L.-S.; Wang, W.* “Highly Enantioselective Organocatalytic Michael Addition Reactions of Ketones with Chalcones” Adv. Synth. Catal., 2006, 348, 425-428.


  1. Zu, L.-S.; Wang, J.; Li, H.; Yu, X-H.; Wang, W.* “Highly Enantioselective Aldehyde-Nitroolefin Michael Addition Reactions Catalyzed by Recyclable Fluorous (S) Diphenylpyrrolinol Silyl Ether” Tetrahedron Lett., 2006, 47, 5131-5134.


  1. Zhang, S.-L.; Duan, W.-H.;* Wang, W.* “Efficient, Enantioselective Organocatalytic Synthesis of Trichostatin A” Adv. Synth. Catal., 2006, 348, 1228-1234.


  1. Li, H.; Wang, J.; Zu, L.-S.; Wang, W.* “Organocatalytic Asymmetric Conjugate Addition of Thioacetic Acid to b-Nitrostyrenes” Tetrahedron Lett., 2006, 47, 2585-2589.


  1. Li, H.; Zu, L.-S.; Wang, J.; Wang, W.* “Organocatalytic Asymmetric Conjugate Addition of Thioacetic Acid to Enones” Tetrahedron Lett., 2006, 47, 3145-3148.


  1. Mei, Y.; Bentley, P. A.; Wang, W. “A Selective and Sensitive Chemosensor for Cu2+ Based on 8-Hydroxyquinoline” Tetrahedron Lett., 2006, 47, 2447-2449.


  1. Wang, J.; Li, H.; Lou, B.; Zu, L.-S.; Guo, H.; Wang, W.* “Enantio- and Diastereoselective Michael Addition Reactions of Unmodified Aldehydes and Ketones with Nitroolefins Catalyzed by a Pyrrolidine Sulfonamid” Eur. J. Chem., 2006, 12, 4321-4332.


  1. Wang, J.; Li, H.; Yu, X.-H.; Zu, L-S.; Wang, W.* “Chiral Binaphthyl-Derived Amine-Thiourea Organocatalyst Promoted Asymmetric Morita-Baylis-Hillman Reaction” Org. Lett., 2005, 7, 4293-4296. (This work has been recognized as Org. Lett. Hot Paper)


  1. Wang, J.; Li, H.; Duan, W.-H.; Zu, L-S.; Wang, W.*Organocatalytic Asymmetric Michael Addition of 2,4-Pentandione to NitroolefinsOrg. Lett., 2005, 7, 4713-4716. (This work has been recognized as Org. Lett. Hot Paper)


  1. Wang, J.; Li, H.; Mei, Y.; Lou, B.; Xu, D.; Xie, D.; Guo, H.; and Wang, W.* “Direct, Facile Aldehyde and Ketone a-Selenenylation Reactions Promoted by L-Prolinamide and Pyrrolidine Sulfonamide Organocatalysts” J. Org. Chem. 2005, 70, 5678-5687.


  1. Wang, W.;* Li, H.; Wang, J. “Pyrrolidine Sulfonamide Promoted Direct, Enantioselective Aldol Reactions of a, a-Dialkyl Aldehydes: Synthesis of Quaternary Carbon-Containing b-Hydroxy Carbonyl Compounds” Tetrahedron Lett., 2005, 46, 5077-5079.


  1. Wang, W.;* Li, H.; Wang, J. “Enantioselective, Organocatalytic Mukaiyama-Michael Addition of Silyl Ethers to a, b-Unsaturated Aldehydes” Org. Lett., 2005, 7, 1637-1639.


  1. Wang, W.;* Mei, J.; Li, H.; Wang, J. “A Novel Pyrrolidine Imide Catalyzed Direct Formation of a, b-Unsaturated Ketones from Unmodified Ketones and Aldehydes” Org. Lett., 2005, 7, 601-604. (One of the Most Accessed Articles of Org. Lett. in year of 2005)


  1. Wang, W.;* Wang, J.; and Li, H. “Direct, Highly Enantioselective Pyrrolidine Sulfonamide Catalyzed Michael Addition Reactions of Aldehydes to Nitrostyrenes” Angew. Chem. Int. Ed., 2005, 44, 1369-1371. (This work has been highlighted in Org. Chem. Highlights 2006, January 30. URL: http://www.organic-chemistry.org/Highlights/2006/30JanuaryB.shtm)


  1. Wang, W.;* Wang, J.; Li, H. “A Simple and Efficient L-Prolinamide-Catalyzed a-Selenenylation Reactions of Aldehydes,” Org. Lett., 2004, 6, 2817-2820.


  1. Wang, W.;* Li, H. “An Efficient Synthesis of the Intrinsic Fluorescent Peptide Labels, (S) and (R) (6,7-Dimethoxyl-4-coumaryl)alanines via Asymmetric Hydrogenations” Tetrahedron Lett., 2004, 45, 8479-8481.


  1. Wang, W.;* Li, H.; Wang, J., Liao, L.-X. “Direct, Organocatalytic a-Sulfenylation of Aldehydes and Ketones”Tetrahedron Lett., 2004, 45, 8229-8231.


  1. Wang, W.;* Wang, J.; Li, H., Liao, L.-X. “A Novel Amine Sulfonamide Organocatalyst for Promoting Direct, Highly Enantioselective a-Aminoxylation Reactions of Aldehydes and Ketones”, Tetrahedron Lett., 2004, 45, 7235-7238.


  1. Wang, W.;* Wang, J.; Li, H. “Catalysis of Highly Stereoselective Mannich-Type Reactions of Ketones with a-Imino Esters by a Pyrrolidine Sulfonamide. Synthesis of Unnatural a-Amino Acids,” Tetrahedron Lett., 2004, 45, 7243-7246.


Before joining UNM (post-doc and graduate work):


  1. Zhang, J.; Wang, W.;* Xiong, C.; and Hruby, V.J.* “Efficient and Stereoselective Synthesis of cis-4-Substittued Proline AnaloguesTetrahedron Lett., 2003, 44, 1413-1415.


  1. Xiong, C.; Zhang, J.; Davis, P.; Wang, W.; Ying, J.; Porreca, F.; and Hruby, V.J. “Stereoselective Synthesis of Individual Isomers of Leu-Enkephalin Analogues Containing Substituted b-Turn Bicyclic Dipeptide MimeticsChem. Commun., 2003, 1598-1599.


  1. Zhang, J.; Xiong, C.; Ying, J.; Wang, W.; Hruby, V.J. “Stereoselective Synthesis of Dipeptide b-Turn Mimeitcs Targeting Melanocortin Receptors: 4,8-Disubstituted Azabicyclo[4.3.0]nonane Amino Acid Esters” Org. Lett., 2003, 5, 3115-3118.


  1. Wang, W.; Zheng, A.; Liu, S.; Wang, B. “Solid Supports, Linkers and Solid-Phase Supported Reagents in Chemical Library Synthesis” in Combinatorial Approaches to Drug Lead Discovery, Liu, G.; Xiao, X.; Wang, J. Eds. page 88~122, Science Press, China, 2003.


  1. Wang, W.; Yang, J.; Ying, J.; Xiong, C.; Zhang, J.; Cai, C.; Hruby, V.J. “Stereoselective Synthesis of Dipeptide b-Turn Mimetics: 7-Benzyl and 8-Phenyl Substituted Azabicyclo[4.3.0] Amino Acids” J. Org. Chem., 2002, 67, 6353-6360.


  1. Wang, W.; Cai, M., Xiong, C.; Zhang, J.; Tevil, D.; Hruby, V.J. “Design and Synthesis of Novel c2-Constrained Phenylalanine, Naphthylalanine, and Tryptophan Analogues and their Use in Biologically Active Melanotropin Peptides” Tetrahedron, 2002, 58, 7365-7374.


  1. Zhang, J.; Xiong, C.; Wang, W.; Ying, J.; Hruby, V.J. “Stereoselective Bromination-Suzuki Cross-Coupling of Dehydroamino Acids to Form Novel Reverse-Turn Peptidomimetics: Substituted Unsaturated and Saturated Indolizidinone Amino Acids” Org. Lett., 2002, 4, 4029-4032.


  1. Wang, W.; Gao, X.; Wang, B. “Boronic Acid-Based Sensors for Carbohydrates” Curr. Org. Chem, 2002, 6, 1285-1317.


  1. Gao, S.; Wang, W.; Wang, B. “Molecularly Imprinted Polymers as Recognition Elements in Optical Sensors” in Optical Sensors, Yan, M.; Ramström, O. Eds., Marcel Dekker, Inc., 2002, invited book chapter.


  1. Xiong, C.; Wang, W.; Hruby, V.J. “A General Asymmetric Synthesis of syn and anti-b-Substituted Cysteine and Serine Derivatives” J. Org. Chem., 2002, 67, 3514-3517.


  1. Wang, W.; Zhang, J.; Xiong, C.; Hruby, V.J. “Design and Synthesis of Hydrophobic, Bulky c2-Constrained Phenylalanine and Naphthylalanine Derivatives” Tetrahedron Lett., 2002, 43, 2137-2140.


  1. Xiong, C.; Wang, W.; Hruby, V.J. “Regioselective and Stereoselective Nucleophilic Ring Opening Reactions of a Phenyl Substituted Aziridine: Enantioselective Synthesis of b-Substituted Tryptophan, Cysteine, and Serine Derivatives” J. Org. Chem., 2002, 67, 1339-1402.


  1. Wang, W.; Xiong, C.; Zhang, J.; Hruby, V.J. “Practical, Asymmetric Synthesis of Aromatic-Substituted Bulky and Hydrophobic Tryptophan and Phenylalanine Derivatives” Tetrahedron, 2002, 58, 3101-3110.


  1. Wang, W.; Xiong, C.; Hruby, V.J. “An Efficient Synthesis of (2S, 6S) and meso-(2S, 6R)-Diaminopimelic Acids via Asymmetric Hydrogenation” Synthesis, 2002, 94-98.


  1. Wang, W.; Xiong, C.; Hruby, V.J. “An Efficient Approach to Asymmetric Synthesis of Dipeptide b-Turn Mimetics: Indolizidinone Amino Acids” Tetrahedron Lett., 2001, 42, 3159-3161.


  1. Wang, W.; Xiong, C.; Hruby, V.J. “Two Novel and Efficient Approaches to Synthesis of Enantiopure Dipeptide b-Turn Mimetics: Indolizidinone Amino Acids” In Peptides: The Wave of the Future: Proceeding of the 16th American Peptide Symposium/2nd International Peptide Symposium, R.A. Houghten and M. Lebl, Editors. 2001, 30-31.


  1. Cai, C.; Wang, W.; Xiong, C.; Soloshonok, V.A.; Cai, M.; Hruby, V.J. “Synthesis of Novel b and g-Substituted Prolines for Conformation-Activity Relationship Studies of the a-MSH Analogues MT-II” In Peptides: The Wave of the Future: Proceeding of the 16th American Peptide Symposium/2nd International Peptide Symposium, R.A. Houghten and M. Lebl, Editors. 2001, 20-21.


  1. Xiong, C.; Wang, W.; Cai, C.; Hruby, V.J. “The Novel Asymmetric Synthesis of b-Fuctionalized Phenylalanine Derivatives” In Peptides: The Wave of the Future: Proceeding of the 16th American Peptide Symposium/2nd International Peptide Symposium, R.A. Houghten and M. Lebl, Editors. 2001, 24-25.


  1. Xiong, C.; Wang, W.; Hruby, V.J. “The General Asymmetric Synthesis of Syn and Anti-b-Substituted Cysteine and Serine Derivatives” In Peptides: The Wave of the Future: Proceeding of the 16th American Peptide Symposium/2nd International Peptide Symposium, R.A. Houghten and M. Lebl, Editors. 2001, 22-23.


  1. Wang, W.; Xiong, C.; Yang, J.; Hruby, V.J. “Practical, Asymmetric Synthesis of Aromatic-substituted Bulky and Hydrophobic Tryptophan Derivatives” Tetrahedron Lett., 2001, 42, 7717-7719.


  1. Springsteen, G., Ballard, C.E., Gao, S.; Wang, W.; Wang, B. "The Developemnt of Photometric Sensors for Boronic Acids" Bioorg. Chem., 2001, 29, 259-270.


  1. Gao, S.; Wang, W.; Wang, B. "Building Fluorescent Sensors for Carbohydrates Using Templated-directed Polymerizations" Bioorg. Chem., 2001, 29, 308-320.


  1. Gao, S.; Wang, W.; Wang, B. “A Novel OsO4-Catalyzed Carbon-Carbon Bond Cleavage Reaction to Give Anthraquinone” Chemistry Lett., 2001, 48-49.


  1. Jiang, J.; Wang, W.; Sane, D.C.; Wang, B. “Synthesis of RGD Analogs as Potential Vectors for Targeted Drug Delivery” Bioorg. Chem., 2001, 29, 357-379.


  1. Wang, W.; Borchardt, R.T.; Wang, B. “Orally Active Peptidomimetic RGD Analogs that are Glycoprotein IIb/IIIa Antagonists” Curr. Med. Chem., 2000, 7, 437-453.


  1. Wang, W.; Springsteen, G.; Gao, S.; Wang, B. "The First Fluorescent Sensor for Boronic and Boric Acids with Sensitivity at Sub-micromolar Concentrations" Chem. Comm. 2000, 1283-1284.


  1. Wang, W.; Borchardt, R.T.; Sane, D.C.; Wang, B. “Delivering Peptides and Peptidomimetics across Membrane Barriers. A Prodrug Approach” In Peptides for New Millennium: Proceeding of the 16th American Peptide Symposium, G.B. Fields, J.P. Tam, G. Barany, Editors. Kluwer Academic Publishers, the Netherlands, 2000, 214-216.


  1. Wang, W.; Camenisch, G.; Sane, D.C.; Zhang, H.; Hugger, E.; Wheeler, G.L.; Borchardt, R.T.; Wang, B."The Use of Prodrug Strategy to Optimize the Oral Absorption of RGD Peptidomimetics J. Controlled Release, 2000, 65, 245-251.


  1. Shan, D.; Zheng, A.; Ballard, C.E.; Wang, W.; Borchardt, R.T.; Wang, B. "A Facilitated Cyclic Ether Formationand its Potential Application in Solid-phase Peptide and Organic Synthesis" Chem. Pharm. Bull. 2000, 48, 238-244.


  1. Wang, W.; Gao, S.; Wang, B. "Building Fluorescent Sensors by Template Polymerization: The Preparation of a Fluorescent Sensor for D-Fructose" Org. Lett., 1999, 1, 1209-1212.


  1. Wang, W.; Jiang, J.; Ballard, C.E.; Wang, B. "Prodrug Approaches to the Improved Delivery of Peptide Drugs" Curr. Pharm. Design, 1999, 5, 265-287.


  1. Liao, Y.; Wang, W.; Wang, B. "Building Fluorescent Sensors by Template Polymerization: The Preparation of a Fluorescent Sensor for L-Tryptophan" Bioorg. Chem., 1999, 27, 463-476.


  1. Wang, B.; Nimkar, K.; Wang, W.; Zhang, H.; Shan, D.; Gudmundsson, O.S.; Gangwar, S.; Siahaan, T.; Borchardt, R.T. "Synthesis and Evaluation of the Physicochemical Properties of Esterase-Sensitive Cyclic Prodrugs of Opioid Peptides Using Coumarinic Acid and Phenylpropionic Acid Linkers" J. Peptide Res. 1999, 53, 370-382.


  1. Borchardt, R.T.; Camenisch, G.; Hugger, E.; Wang, W.; Sane, D.C.; Wheeler, G.L.; Cheng, C.-P.; Wang, B. " Prodrug Strategies to Improve the Oral Absorption of Peptide Mimetics" Polymer Preprints, 1999, 40(1), 257-258.


  1. Zheng, A.; Wang, W.; Zhang, H.; Wang, B. "Two New Improved Approaches to the Synthesis of Coumarin-Based Prodrugs" Tetrahedron 1999, 55, 4237-4254.


  1. Gudmundsson, O.S.; Pauletti, G.M.; Wang, W.; Shan, D.; Zhang, H.; Wang, B.; Borchardt R.T. "Coumarin-Based Cyclic Prodrugs of Opioid Peptides that Exhibit Metabolic Stability to Peptidases and Excellent Cellular Permeability" Pharm. Res. 1999, 16, 7-15.


  1. Wang, B.; Wang, W.; Camenisch, G.P.; Elmo, J.; Zhang, H.; Borchardt, R.T. "Synthesis and Evaluation of Novel Coumarin-Based Esterase-Sensitive Cyclic Prodrugs of Peptidomimetic RGD Analogs with Improved Membrane Permeability" Chem. Pharm. Bull. 1999, 47, 90-95.


  1. Liao, Y.; Wang, W.; Wang, B. "Enantioselective Polymeric Transporters of D-Tryptophan Prepared Using Molecular Imprinting Techniques" Bioorg. Chem. 1998, 26, 309-322.


  1. Gudmundsson, O.S.; Bak, A.; Wang, W.; Shan, D.; Zhang, H.; Friis, G.J., Wang, B.; Borchardt, R.T. "Prodrug Strategies to Enhance the Permeation of Opioid Peptides through the Intestinal Mucosa" Peptide and Protein Drug Delivery, S. Frokjer, L. Christruecrd, P. Krogsgard, Editors. Munksgaard, Denmark, 1998, p 259-269.


  1. Camenisch, G.P.; Wang, W.; Wang, B.; Borchardt, R.T. "A Comparison of the Bioconversion Rates and the Caco-2 Cell Permeation Characteristics of Coumarin-Based Cyclic Prodrugs and Methylester-Baesd Linear Prodrugs of RGD Peptidomimetics" Pharm. Res. 1998, 15, 1174-1181.


  1. Wang, B.; Shan, D.; Wang, W.; Zhang, H.; Gudmundsson, O.S.; Borchardt, R.T. "Synthesis of Coumarin-Based, Esterase-Sensitive Cyclic Prodrugs of Opioid Peptides with Enhanced Membrane Permeability and Enzymatic Stability" Methods in Molecular Medicine Kazmierski, W.; Walker, J.M. Editors. Humana Press Inc., Totowa, NJ. 1998, 71-85.


  1. Wang, B.; Zhang, H.; Zheng, A.; Wang, W. "Coumarin-Based Prodrugs. Part 3: Structural Effects on the Release Kinetics of Esterase-sensitive Prodrugs of Amines" Bioorg. Med. Chem. 1998, 6, 417-426.


  1. Benbrook, D.M.; Madler, M.M.; Spruce, L.W.; Birckbichler, P.J.; Nelson, E.C.; Subramanian, S.; Weerasekare, G.M.; Gale, J.B.; Patterson, M.K.Jr.; Wang, B.; Wang, W.; Lu, S.; Rowland, T.C.; DiSivestio, P.; Berlin, K.D. "Biologically Active Heteroarotinoids Exhibiting Anticancer Activity and Decrease Toxicity" J. Med. Chem. 1997, 40, 3567-3583.


  1. Wang, B.; Wang, W.; Zhang, H.; Shan, D.; Smith, T.D. "Coumarin-Based Prodrugs 2. Synthesis and Bioreversibility Studies of an Esterase-sensitive Cyclic Prodrug of DADLE, an Opioid Peptide" Bioorg. Med. Chem. Lett. 1996, 6, 2823-2826.


  1. Wang, B.; Zhang, H.; Wang, W. "Chemical Feasibility Studies of a Potential Coumarin-Based Prodrug System" Bioorg. Med. Chem. Lett. 1996, 6, 945-950.


Patents (2 total)


  1. Wang, W.; Wang, J.; Li, H. “Organocatalysis and Methods of Use in Chemical Synthesis” WO 2006007586 (2006).


  1. Fan, Y.; Gao, W.; Gray, N.S.; Hinterding, K.; Lefebvre, S.; Mi, Y.; Nussbaumer, P.; Pan, S.; Wang, W.; Zecri, F.; Perez, L. B.; La Montagne, K.R.; Ettmayer, P. (Novartis A.-G., Switz.; Novartis Pharma G.m.b.H.; IRM LLC). “Bis-aromatic alkanols” Patent No. WO 2003099192