Lipolysis
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Course Outline
Lecture Notes
Readings

Lipolysis and Fatty Acid Oxidation

a) Classic Studies

Harris RC, Foster CV, Hultman E. Acetylcarnitine formation during intense muscular contraction in humans. J Appl Physiol. 1987 Jul;63(1):440-2.

Hiatt WR, Regensteiner JG, Wolfel EE, Ruff L, Brass EP. Carnitine and acylcarnitine metabolism during exercise in humans. Dependence on skeletal muscle metabolic state. J Clin Invest. 1989 Oct;84(4):1167-73.

Sahlin K. Muscle carnitine metabolism during incremental dynamic exercise in humans. Acta Physiol Scand. 1990 Mar;138(3):259-62.

b) Recent Research

Angus DJ, Hargreaves M, Dancey J, Febbraio MA. Effect of carbohydrate or carbohydrate plus medium-chain triglyceride ingestion on cycling time trial performance. J Appl Physiol. 2000 Jan;88(1):113-9.

Bergman BC, Butterfield GE, Wolfel EE, Casazza GA, Lopaschuk GD, Brooks GA. Evaluation of exercise and training on muscle lipid metabolism. Am J Physiol. 1999 Jan;276(1 Pt 1):E106-17.

Brass EP, Hiatt WR. Carnitine metabolism during exercise. Life Sci. 1994;54(19):1383-93.

Brouns F, van der Vusse GJ. Utilization of lipids during exercise in human subjects: metabolic and dietary constraints. Br J Nutr. 1998 Feb;79(2):117-28.

Chilibeck PD, Bell GJ, Farrar RP, Martin TP. Higher mitochondrial fatty acid oxidation following intermittent versus continuous endurance exercise training. Can J Physiol Pharmacol. 1998 Sep;76(9):891-4.

Coggan AR, Raguso CA, Gastaldelli A, Sidossis LS, Yeckel CW. Fat metabolism during high-intensity exercise in endurance-trained and untrained men. Metabolism. 2000 Jan;49(1):122-8.

Constantin-Teodosiu D, Howell S, Greenhaff PL. Carnitine metabolism in human muscle fiber types during submaximal dynamic exercise. J Appl Physiol. 1996 Mar;80(3):1061-4.

Coyle EF, Jeukendrup AE, Wagenmakers AJ, Saris WH. Fatty acid oxidation is directly regulated by carbohydrate metabolism during exercise. Am J Physiol. 1997 Aug;273(2 Pt 1):E268-75.

Dyck DJ, Putman CT, Heigenhauser GJ, Hultman E, Spriet LL. Regulation of fat-carbohydrate interaction in skeletal muscle during intense aerobic cycling. Am J Physiol. 1993 Dec;265(6 Pt 1):E852-9.

Friedlander AL, Casazza GA, Horning MA, Usaj A, Brooks GA. Endurance training increases fatty acid turnover, but not fat oxidation, in young men. J Appl Physiol. 1999 Jun;86(6):2097-105.

Friolet R, Hoppeler H, Krahenbuhl S. Relationship between the coenzyme A and the carnitine pools in human skeletal muscle at rest and after exhaustive exercise under normoxic and acutely hypoxic conditions. J Clin Invest. 1994 Oct;94(4):1490-5.

Hawley JA, Brouns F, Jeukendrup A. Strategies to enhance fat utilization during exercise. Sports Med. 1998 Apr;25(4):241-57.

Holloszy JO, Kohrt WM, Hansen PA. The regulation of carbohydrate and fat metabolism during and after exercise. Front Biosci. 1998 Sep 15;3:D1011-27.

Horowitz JF, Mora-Rodriguez R, Byerley LO, Coyle EF. Preexercise medium-chain triglyceride ingestion does not alter muscle glycogen use during exercise. J Appl Physiol. 2000 Jan;88(1):219-25.

Horowitz JF, Klein S. Lipid metabolism during endurance exercise. Am J Clin Nutr. 2000 Aug;72(2 Part 2):558S-563S.

Horowitz JF, Mora-Rodriguez R, Byerley LO, Coyle EF. Lipolytic suppression following carbohydrate ingestion limits fat oxidation during exercise. Am J Physiol. 1997 Oct;273(4 Pt 1):E768-75.

Jeukendrup AE, Saris WH, Van Diesen R, Brouns F, Wagenmakers AJ. Effect of endogenous carbohydrate availability on oral medium-chain triglyceride oxidation during prolonged exercise. J Appl Physiol. 1996 Mar;80(3):949-54.

Jeukendrup AE, Saris WH, Wagenmakers AJ. Fat metabolism during exercise: a review--part III: effects of nutritional interventions. Int J Sports Med. 1998 Aug;19(6):371-9.

Jeukendrup AE, Saris WH, Wagenmakers AJ. Fat metabolism during exercise: a review--part II: regulation of metabolism and the effects of training. Int J Sports Med. 1998 Jul;19(5):293-302.

Jeukendrup AE, Saris WH, Wagenmakers AJ. Fat metabolism during exercise: a review. Part I: fatty acid mobilization and muscle metabolism. Int J Sports Med. 1998 May;19(4):231-44.

Kanaley JA, Mottram CD, Scanlon PD, Jensen MD. Fatty acid kinetic responses to running above or below lactate threshold. J Appl Physiol. 1995 Aug;79(2):439-47.

Kiens B, Roemen TH, van der Vusse GJ. Muscular long-chain fatty acid content during graded exercise in humans. Am J Physiol. 1999 Feb;276(2 Pt 1):E352-7.

Kiens B. Training and fatty acid metabolism. Adv Exp Med Biol. 1998;441:229-38.

Kiens B. Effect of endurance training on fatty acid metabolism: local adaptations. Med Sci Sports Exerc. 1997 May;29(5):640-5.

Klein S, Weber JM, Coyle EF, Wolfe RR. Effect of endurance training on glycerol kinetics during strenuous exercise in humans. Metabolism. 1996 Mar;45(3):357-61.

Krssak M, Petersen KF, Bergeron R, Price T, Laurent D, Rothman DL, Roden M, Shulman GI.

Intramuscular glycogen and intramyocellular lipid utilization during prolonged exercise and recovery in man: a 13C and 1H nuclear magnetic resonance spectroscopy study. J Clin Endocrinol Metab. 2000 Feb;85(2):748-54.

Martin WH 3rd. Effect of endurance training on fatty acid metabolism during whole body exercise. Med Sci Sports Exerc. 1997 May;29(5):635-9.

Morio B, Montaurier C, Ritz P, Fellmann N, Coudert J, Beaufrere B, Vermorel M. Time-course effects of endurance training on fat oxidation in sedentary elderly people. Int J Obes Relat Metab Disord. 1999 Jul;23(7):706-14.

Mulla NA, Simonsen L, Bulow J. Post-exercise adipose tissue and skeletal muscle lipid metabolism in humans: the effects of exercise intensity. J Physiol. 2000 May 1;524 Pt 3:919-28.

Odland LM, Howlett RA, Heigenhauser GJ, Hultman E, Spriet LL. Skeletal muscle malonyl-CoA content at the onset of exercise at varying power outputs in humans. Am J Physiol. 1998 Jun;274(6 Pt 1):E1080-5.

Odland LM, Heigenhauser GJ, Wong D, Hollidge-Horvat MG, Spriet LL. Effects of increased fat availability on fat-carbohydrate interaction during prolonged exercise in men. Am J Physiol. 1998 Apr;274(4 Pt 2):R894-902.

Odland LM, Heigenhauser GJ, Lopaschuk GD, Spriet LL. Human skeletal muscle malonyl-CoA at rest and during prolonged submaximal exercise. Am J Physiol. 1996 Mar;270(3 Pt 1):E541-4.

Okano G, Sato Y, Murata Y. Effect of elevated blood FFA levels on endurance performance after a single fat meal ingestion. Med Sci Sports Exerc. 1998 May;30(5):763-8.

Pitsiladis YP, Smith I, Maughan RJ. Increased fat availability enhances the capacity of trained individuals to perform prolonged exercise. Med Sci Sports Exerc. 1999 Nov;31(11):1570-9.

Rasmussen BB, Wolfe RR. Regulation of fatty acid oxidation in skeletal muscle. Annu Rev Nutr. 1999;19:463-84.

Rasmussen BB, Winder WW. Effect of exercise intensity on skeletal muscle malonyl-CoA and acetyl-CoA carboxylase. J Appl Physiol. 1997 Oct;83(4):1104-9.

Romijn JA, Coyle EF, Sidossis LS, Zhang XJ, Wolfe RR. Relationship between fatty acid delivery and fatty acid oxidation during strenuous exercise. J Appl Physiol. 1995 Dec;79(6):1939-45.

Romijn JA, Coyle EF, Sidossis LS, Rosenblatt J, Wolfe RR. Substrate metabolism during different exercise intensities in endurance-trained women. J Appl Physiol. 2000 May;88(5):1707-14.

Sial S, Coggan AR, Carroll R, Goodwin J, Klein S. Fat and carbohydrate metabolism during exercise in elderly and young subjects. Am J Physiol. 1996 Dec;271(6 Pt 1):E983-9.

Sidossis LS, Wolfe RR, Coggan AR. Regulation of fatty acid oxidation in untrained vs. trained men during exercise. Am J Physiol. 1998 Mar;274(3 Pt 1):E510-5.

Sidossis LS, Gastaldelli A, Klein S, Wolfe RR. Regulation of plasma fatty acid oxidation during low- and high-intensity exercise. Am J Physiol. 1997 Jun;272(6 Pt 1):E1065-70.

Spriet LL, MacLean DA, Dyck DJ, Hultman E, Cederblad G, Graham TE. Caffeine ingestion and muscle metabolism during prolonged exercise in humans. Am J Physiol. 1992 Jun;262(6 Pt 1):E891-8.

Tate CA, Holtz RW. Gender and fat metabolism during exercise: a review. Can J Appl Physiol. 1998 Dec;23(6):570-82.

Turcotte LP. Role of fats in exercise. Types and quality. Clin Sports Med. 1999 Jul;18(3):485-98.

Whitley HA, Humphreys SM, Campbell IT, Keegan MA, Jayanetti TD, Sperry DA, MacLaren DP, Reilly T, Frayn KN. Metabolic and performance responses during endurance exercise after high-fat and high-carbohydrate meals. J Appl Physiol. 1998 Aug;85(2):418-24.

Winder WW. Intramuscular mechanisms regulating fatty acid oxidation during exercise. Adv Exp Med Biol. 1998;441:239-48.

Winder WW. Malonyl-CoA--regulator of fatty acid oxidation in muscle during exercise. Exerc Sport Sci Rev. 1998;26:117-32.

Wolfe RR. Fat metabolism in exercise. Adv Exp Med Biol. 1998;441:147-56.