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Note: CV refers to Cardiovascular Disease
With insulin resistance, insulin is not reacting effectively with the insulin receptors on the muscle. Exercise independently activates the protein receptors which in turn activate the GLUT4 shuttle proteins to intake glucose.
Note that during exercise with untrained and trained persons that insulin levels drop.The contracting muscles activate the protein receptors on muscle which activate the GLUT4 shuttle proteins (thus, increasing the transport of glucose into the contracting muscle cells). Also, epinephrine and norepinephrine inhibit insulin release from the pancreas.