Ex Phys Home
Class, make sure you can DRAW and LABEL this graphic completely. This clearly shows the negative feedback loop not working with a person with Type 2 diabetes. CV refers to Cardiovascular Disease
With insulin resistance, insulin is not reacting effectively with the insulin receptors on the muscle. Importantly, exercise independently activates the GLUT4 shuttle proteins to intake glucose. This is referred to as an increase in sensitivity to insulin, but it actually is the independent effect of exercise on the GLUT4 translocator proteins.
Note that during exercise with untrained and trained persons that insulin levels drop. The contracting muscles activate the GLUT4 shuttle proteins (thus, increasing the transport of glucose into the contracting muscle cells). Also, epinephrine and norepinephrine inhibit insulin release from the pancreas.