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Peripheral Fatigue
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| Neuromuscular Junction: With neuromuscular junction there is a breakdown of ACh in getting to the motor end plate resulting in NO muscle contraction. The mechanism for this breakdown is not well-known. | ||||||||
| Two sites in muscle: At one site, the H+ ions interfere with calcium ions from binding to troponin. The interference PREVENTS the configuration shift of tropomyosin to reveal the active bidings sites. In the other site, the increase in acidosis (from the H+ ion accumulation) denatures the enzyme ATPase, inhibiting the splitting of ATP to ADP and Pi and energy. Remember, the H+ accumulation is coming from the hydrolysis of ATP during the exercise bout. | ||||||||
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