Hypoxia

Course Outline
Study Notes
Readings
593eee Labs
Study Guides

2001, 2002

Brutsaert TD, Spielvogel H, Caceres E, Araoz M, Chatterton RT, Vitzthum VJ. Effect of menstrual cycle phase on exercise performance of high-altitude native women at 3600m. J Exp Biol. 2002 Jan 15;205(Pt 2):233-239.

Sandoval DA, Matt KS. Gender differences in the endocrine and metabolic responses to hypoxic exercise. J Appl Physiol. 2002 Feb;92(2):504-12.

Yamaya Y, Bogaard HJ, Wagner PD, Niizeki K, Hopkins SR. Validity of pulse oximetry during maximal exercise in normoxia, hypoxia, andhyperoxia. J Appl Physiol. 2002 Jan;92(1):162-8.

Gore CJ, Hahn AG, Aughey RJ, Martin DT, Ashenden MJ, Clark SA, Garnham AP, Roberts AD, Slater GJ, McKenna MJ. Live high:train low increases muscle buffer capacity and submaximal cyclingefficiency. Acta Physiol Scand. 2001 Nov;173(3):275-86.

van Hall G, Calbet JA, Sondergaard H, Saltin B. The re-establishment of the normal blood lactate response to exercise in humans after prolonged acclimatization to altitude. J Physiol. 2001 Nov 1;536(Pt 3):963-75.

Lundby C, Araoz M, van Hall G. Peak heart rate decreases with increasing severity of acute hypoxia. High Alt Med Biol. 2001 Fall;2(3):369-76.

Peltonen JE, Tikkanen HO, Ritola JJ, Ahotupa M, Rusko HK. Oxygen uptake response during maximal cycling in hyperoxia, normoxia and hypoxia. Aviat Space Environ Med. 2001 Oct;72(10):904-11.

Noakes TD, Peltonen JE, Rusko HK. Evidence that a central governor regulates exercise performance during acute hypoxia and hyperoxia. J Exp Biol. 2001 Sep;204(Pt 18):3225-34.

Lindstedt SL, Conley KE. Human aerobic performance: too much ado about limits to V(O(2)). J Exp Biol. 2001 Sep;204(Pt 18):3195-9.

Hoppeler H, Vogt M. Muscle tissue adaptations to hypoxia. J Exp Biol. 2001 Sep;204(Pt 18):3133-9.

Schoene RB. Limits of human lung function at high altitude. J Exp Biol. 2001 Sep;204(Pt 18):3121-7.

Kuwahira I, Moue Y, Urano T, Kamiya U, Iwamoto T, Ishii M, Clancy RL, Gonzalez NC. Redistribution of pulmonary blood flow during hypoxic exercise. Int J Sports Med. 2001 Aug;22(6):393-9.

Peltonen JE, Tikkanen HO, Rusko HK. Cardiorespiratory responses to exercise in acute hypoxia, hyperoxia and normoxia. Eur J Appl Physiol. 2001 Jul;85(1-2):82-8.

Anchisi S, Moia C, Ferretti G. Oxygen delivery and oxygen return in humans exercising in acute normobaric hypoxia. Pflugers Arch. 2001 Jun;442(3):443-50.

Bartsch P, Grunig E, Hohenhaus E, Dehnert C. Assessment of high altitude tolerance in healthy individuals. High Alt Med Biol. 2001 Summer;2(2):287-96.

Clanton TL, Klawitter PF. Invited review: Adaptive responses of skeletal muscle to intermittent hypoxia: the known and the unknown. J Appl Physiol. 2001 Jun;90(6):2476-87.

Henderson KK, Clancy RL, Gonzalez NC. Living and training in moderate hypoxia does not improve VO2 max more than living and training in normoxia. J Appl Physiol. 2001 Jun;90(6):2057-62.

Hahn AG, Gore CJ, Martin DT, Ashenden MJ, Roberts AD, Logan PA. An evaluation of the concept of living at moderate altitude and training at sea level. Comp Biochem Physiol A Mol Integr Physiol. 2001 Apr;128(4):777-89.

Lundby C, van Hall G. Peak heart rates at extreme altitudes. High Alt Med Biol. 2001 Spring;2(1):41-5.

Neubauer JA. Invited review: Physiological and pathophysiological responses to intermittent hypoxia. J Appl Physiol. 2001 Apr;90(4):1593-9.

Katayama K, Sato Y, Morotome Y, Shima N, Ishida K, Mori S, Miyamura M. Intermittent hypoxia increases ventilation and Sa(O2) during hypoxic exercise and hypoxic chemosensitivity. J Appl Physiol. 2001 Apr;90(4):1431-40.

Weston AR, Mackenzie G, Tufts MA, Mars M. Optimal time of arrival for performance at moderate altitude (1700 m. Med Sci Sports Exerc. 2001 Feb;33(2):298-302.

1996-2000

Roach RC, Maes D, Sandoval D, Robergs RA, Icenogle M, Hinghofer-Szalkay H, Lium D, Loeppky JA. Exercise exacerbates acute mountain sickness at simulated high altitude. J Appl Physiol. 2000 Feb;88(2):581-5.

Ashenden MJ, Gore CJ, Dobson GP, Boston TT, Parisotto R, Emslie KR, Trout GJ, Hahn AG. Simulated moderate altitude elevates serum erythropoietin but does not increase reticulocyte production in well-trained runners. Eur J Appl Physiol. 2000 Mar;81(5):428-35.

Ashenden MJ, Gore CJ, Dobson GP, Hahn AG. "Live high, train low" does not change the total haemoglobin mass of male endurance athletes sleeping at a simulated altitude of 3000 m for 23 nights. Eur J Appl Physiol. 1999 Oct;80(5):479-84.

Stray-Gundersen J, Levine BD. "Living high and training low" can improve sea level performance in endurance athletes. Br J Sports Med. 1999 Jun;33(3):150-1.

Bernhard WN, Schalick LM, Delaney PA, Bernhard TM, et al. Acetazolamide plus low-dose dexamethasone is better than acetazolamide alone to ameliorate symptoms of acute mountain sickness. Aviat. Spae, Environ. Med. 1998;69(9):883-886.

Robergs RA, Quintana R, Parker DL, Frankel CC. Multiple variables explain the variability in the decrement in VO2max during acute hypobaric hypoxia. Med Sci Sports Exerc. 1998 Jun;30(6):869-79.

Chapman RF, Stray-Gundersen J, Levine BD. Individual variation in response to altitude training. J Appl Physiol. 1998 Oct;85(4):1448-56.

Rostrup M. Catecholamines, hypoxia and high altitude. Acta Physiol. Scand. 1998;162:389-399.

Emonson DL, Aminuddin AH, Wight RL, Scroop GC, Gore CJ. Training-induced increases in sea level VO2max and endurance are not enhanced by acute hypobaric exposure. Eur J Appl Physiol. 1997;76(1):8-12.

Levine BD, Stray-Gundersen J. "Living high-training low": effect of moderate-altitude acclimatization with low-altitude training on performance. J Appl Physiol. 1997 Jul;83(1):102-12.

Ferretti G, Moia C, Thomet JM, Kayser B. The decrease of maximal oxygen consumption during hypoxia in man: a mirror image of the oxygen equilibrium curve. J. Physiol. 1997;498(1):231-237.

Gore CJ, Little SC, Hahn AG, Scroop GC, Norton KI, Bourdon PC, Woolford SM, Buckley JD, Stanef T, Campbell DP, Watson DB, Emonson DL. Reduced performance of male and female athletes at 580 m altitude. Eur J Appl Physiol. 1997;75(2):136-43.

Gore CJ, Hahn AG, Scroop GC, Watson DB, et al. Increased arterial desaturation in trained cyclists during maximal exercise at 580 m altitude. J. Appl. Physiol. 1996;80(6):2204-2210, 1996.

Kayser B. Lactate during exercise at high altitude. Eur J Appl Physiol. 1996;74(3):195-205.

Yamamoto Y, Hoshikawa Y, Miyashita M. Effects of acute exposure to simulated altitude on heart rate variability during exercise. J Appl Physiol. 1996 Sep;81(3):1223-9.

Wagner P.D. A theoretical analysis of factors determining VO2max at sea level and altitude. Res. Physiol. 1996;106:329-343.

Savourey G, Garcia N, Besnard Y, Guinet A, Hanniquet AM, Bittel J. Pre-adaptation, adaptation and de-adaptation to high altitude in humans: cardio-ventilatory and haematological changes. Eur J Appl Physiol. 1996;73(6):529-35.

Roberts AC, Butterfield GE, Cymerman A, Reeves JT, Wolfel EE, Brooks GA. Acclimatization to 4,300-m altitude decreases reliance on fat as a substrate. J Appl Physiol. 1996 Oct;81(4):1762-71.

1991-1995

Richardson RS, Knight DR, Poole DC, Kurdak SS, et al. Determinants of maximal exercise VO2 during single leg knee-extensor exercise in humans. Am. J. Physiol. 1995;268(37):H1453-H1461.

Favier R, Spielvogel H, Desplanches D, Ferretti G, Kayser B, Grunenfelder A, Leuenberger M, Tuscher L, Caceres E, Hoppeler H. Training in hypoxia vs. training in normoxia in high-altitude natives. J Appl Physiol. 1995 Jun;78(6):2286-93.

Hughson RL, Green HJ, Sharratt MT. Gas exchange, blood lactate, and plasma catecholamines during incremental exercise in hypoxia and normoxia. J. Appl. Physiol. 1995;79(4):1134-1141.

Koistinen P, Takala T, Martikkala V, Leppaluoto J. Aerobic fitness influences the response of maximal oxygen uptake and lactate threshold in acute hypobaric hypoxia. Int J Sports Med. 1995 Feb;16(2):78-81.

Grassi B, Ferretti G, Kayser B, Marzorati M, Colombini A, et al. Maximal rate of blood lactate accumulation during exercise at altitude in humans. J. Appl. Physiol. 1995;79(1):331-339.

Coote JH. Medicine and mechanisms in altitude sickness. Recommendations. Sports Med. 1995 Sep;20(3):148-59.

Engfred K, Kjaer M, Secher NH, Friedman DB, Hanel B, Nielsen OJ, Bach FW, Galbo H, Levine BD. Hypoxia and training-induced adaptation of hormonal responses to exercise in humans. Eur J Appl Physiol. 1994;68(4):303-9.

Paul MA, Fraser WD. Performance during mild acute hypoxia. Aviat Space Environ Med. 1994 Oct;65(10 Pt 1):891-9.

Krasney JA. A neurogenic basis for acute altitude illness. Med Sci Sports Exerc. 1994 Feb;26(2):195-208.

Kayser B, Narici M, Binzoni T, Grassi B, Cerretelli P. Fatigue and exhaustion in chornic hypbaric hypoxia: influence of exercising muscle mass. J. Appl. Physiol. 1994;76(2):634-640.

Coudert J. Anaerobic performance at altitude. Int J Sports Med. 1992 Oct;13 Suppl 1:S82-5.

Levine BD, Stray-Gundersen J. A practical approach to altitude training: where to live and train for optimal performance enhancement. Int J Sports Med. 1992 Oct;13 Suppl 1:S209-12.

Green HJ, Sutton JR, Wolfel EE, Reeves JT, Butterfield GE, Brooks GA. Altitude acclimatization and energy metabolic adaptations in skeletal muscle during exercise. J Appl Physiol. 1992 Dec;73(6):2701-8.

Reeves JT, Wolfel EE, Green HJ, Mazzeo RS, Young AJ, Sutton JR, Brooks GA. Oxygen transport during exercise at altitude and the lactate paradox: lessons from Operation Everest II and Pikes Peak. Exerc Sport Sci Rev. 1992;20:275-96.

Richalet JP, Bittel J, Herry JP, Savourney G, Le Trong JL, Auvert JF, Janin C. Use of a hypobaric chamber for pre-acclimatization before climbing Mount Everest. Int. S. Sports Med. 1992;Suppl 1:S216-S220.

Rathat C, Richalet JP, Herry JP, Larmignat P. Detection of high-risk subjects for high altitude diseases. Int J Sports Med. 1992 Oct;13 Suppl 1:S76-8.

Milledge JS. Salt and water control at altitude. Int J Sports Med. 1992 Oct;13 Suppl 1:S61-3.

Pigman EC. Acute mountain sickness. Effects and implications for exercise at intermediate altitudes. Sports Med. 1991 Aug;12(2):71-9.

Wolfel EE, Groves BM, Brooks GA, Butterfield GE. et al. Oxygen transport during steady-state submaximal exercise in chronic hypoxia. J. Appl. Physiol. 1991;70(3):1129-1136.

1986-1990

Stager JM, Tucker A, Cordain L, Engerbretsen BJ, et al. Normoxic and acute hypoxic exercise tolerance in man following acetazolamide. Med. Sci. Sports Exerc. 1990;22(2):178-184.

Cymerman A, Reeves JT, Sutton JR, Rock PB, Groves BM, et al. Operation Everest II: Maximal oxygen uptake at extreme altitude. J. Appl. Physiol. 1989;66(5):2446-2453.

Bender PR, Groves BM, McCullough RE, McCullough RG, Trad L, Young AJ, Cymerman A, Reeves JT. Decreased exercise muscle lactate release after high altitude acclimatization. J Appl Physiol. 1989 Oct;67(4):1456-62.

Oelz O, Maggiorini M, Ritter M, Waber U, Jenni R, Vock P, Bartsch P. Nifedipine for high altitude pulmonary oedema. Lancet. 1989 Nov 25;2(8674):1241-4.

Montgomery AB, Mills J, Luce JM. Incidence of acute mountain sickness at intermediate altitude. JAMA. 1989 Feb 3;261(5):732-4.

Green HJ, Sutton JR, Young P, Cymerman A, Houston CS. Operation Everest II: Muscle energetics during maximal exhaustive exercise. J. Appl. Physiol. 1989;66(1):142-150.

Bender PR, Groves BM, McCullough RE, McCullough RG, et al. Oxygen transport to exercising leg in chronic hypoxia. J. Appl. Physiol. 1988;65(6):2592-2597.

Lawler J, Powers SK, Thompson D. Linear relationship between VO2max and VO2max decrement during exposure to acute hypoxia. J. Appl. Physiol. 1988;64(4):1486-1492.

Reeves JT, Groves BM, Sutton JR, Wagner PD, Cymerman A, et al. Operation Everest II: Preservation of cardiac function at extreme altitude. J. Appl. Physiol. 1987;63(20:531-539.

Wagner PD, Sutton JR, Reeves JT, Cymerman A, Groves BM, Malconian MK. Operation Everest II: Pulmonary gas exchange during a simulated ascent of Mt. Everest. J. Appl. Physiol. 1987;63(6):2348-2359.

Rowell L, Saltin B, Kiens B, Christensen NJ. Is peak quadriceps blood flow in humans even higher during exercise with hypoxemia? Am. J. Physiol. 1986;251:H1038-H1044.

1981-1985

Young AJ, Cymerman A, Burse RL. The influence of cardiorespiratory fitness on the decrement in maximal aerobic power at high altitude. Eur. J. Appl. Physiol. 1985;54:12-15.

Andersen HT, Smeland EB, Owe JO, Myhre K. Analyses of maximum cardiopulmonary performance during exposure to acute hypoxia at simulated altitude – sea level to 5000 meters (760-404 mmHg). Aviation, Space Environ. Med. 1985;56:1192-1197.

Maresh CM, Noble BJ, Robertson KL, Sime WE. Maximal exercise during hypobaric hypoxia (447 Torr) in moderate-altitude natives. Med Sci Sports Exerc. 1983;15(5):360-5.

Hogan MC, Cox RH, Welch HG. Lactate accumulation during incremental exercise with varied inspired oxygen fractions. J. Appl. Physiol. 1983;55(4):1143-1140.

Squires RW, Buskirk ER. Aerobic capacity during acute exposure to simulated altitude, 914-2286 meters. Med. Sci. Sports Exerc. 1982;14(1):36-40.

1980 and before

Horstman D, Weiskopf R, Jackson RE. Work capacity during 3-wk sojourn at 4,300 m: effects of relative polycythemia. J. Appl. Physiol. 1980;49(2):311-318.

Drinkwater BL, Folinsbee LJ, Bedi JF, Plowman SA, Loucks AB, Horvath SM. Response of women mountaineers to maximal exercise during hypoxia. Aviat Space Environ Med. 1979 Jul;50(7):657-62.

Fargraeus L, Linnarsson D, Saltin B. Oxygen uptake during maximal work at lowered and raised ambient air pressures. Acta Physiol. Scand. 1973;87:411-421.

Hughes RL, Clode M, Edwards RHT, Goodwin TJ, Jones NL. Effect of inspired O2 on cardiopulmonary and metabolic responses to exercise in man. J. Appl. Physiol. 1968;24(3):336-347.

Faulkner JA, Kollias J, Vavour CB, Buskirk ER, Balke B. Maximum aerobic capacity and running performance at altitude. J. Appl. Physiol. 1968;24(5):685-691.