Readings
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PEP 426
PEP 593-EEE
PEP 535-EB
Biochem Lab
PEP 593
PEP 627
PEP 528-Neuromuscular Perf.
PEP/HED604
530 Lab. Proced.
Research Methods
PEP 478/579
LabVIEW
PEP 326

The following table provides information of additional reading material. Where possible, this additional reading has been converted to formats accessible through the internet.  To retrieve such resources, such as PDF documents or URL's to other web-based resources, simply click on the content of the "Location" column.

Note that I have listed readings that mostly pertain to an understanding of exercise-induced fatigue. I have spread these out during the course so that you can read this sequentially and progressively over time so that you are better prepared for your assignment, my two lectures on this content, and the debate.

Week/Source Topic Location
Week 1
Overview of Fatigue Hargreaves M. Fatigue mechanisms determining exercise performance: integrative physiology is systems physiology. J Appl Physiol 2008;104:1541-1542. pdf
Overview of Central Governor Theory Noakes TD. St Clair Gibson A, Lambert EV. From catastrophe to complexity: a novel model of integrative central neural regulation of effort and fatigue during exercise in humans: summary and conclusions. Br J Sports Med. 2005;39:120-124. pdf
Week 2
Fatigue at VO2max Noakes TD. Testing for maximal oxygen consumption has produced a brainless model of human exercise performance. Br J Sports Med. 2008;42:551-555. pdf
Support of VO2max concept Levine BD. VO2max: What do we know and what do we still need to know? J Physiol 2008;586.1:25-34. pdf
Fatigue and exercise in the heat Tucker R, Rauch L, Harley YXR, Noakes TD. Impaired exercise performance in the heat is associated with an anticipatory reduction in skeletal muscle recruitment. Pflugers Archives - Eur J Physiol. 2004;448:422-430. pdf
Week 3
Cortical site of fatigue during heat stress Todd G, Butler JE, Taylor JL, Gandevia SC. Hyperthermia: A failure of the motor cortex and the muscle. J Physiol 2005;563.2:621-631. pdf
Evidence of motor cortex and muscle roles in contractile fatigue Taylor JL, Butler JE, Allen GM, Gandevia SC. Changes in motor cortical excitability during human muscle fatigue. J Physiol. 1996;490.2:519-528. pdf
Week 4
smooth  muscle contraction Excitation contraction coupling in smooth muscle website
latch-bride model of smooth  muscle contraction Hai CM, Kim HR. An expanded latch-bridge model of protein kinase C-mediated smooth muscle contraction. J Appl Physiol 2005;98(4):1356-1365. pdf
smooth muscle review Morano I. Tuning smooth muscle contraction by molecular motors pdf
Week 5
biopsy sampling error Lexell J, et al. Analysis of sampling errors in biopsy techniques using data from whole muscle cross sections. J Appl Physiol 1985;59(4):1228-1235. pdf
biopsy sampling error Elder GCB, et al. Variability in fiber type distributions within human skeletal muscle. J Appl Physiol 1982;53(6):1473-1480. pdf
Single fiber study Trappe S, et al. Exercise in space: human skeletal muscle after 6 months aboard the International Space Station. J Appl Physiol 2009;106:1159-1168. pdf
Single fiber study Harber H and Trappe S. Single muscle fiber contractile properties of young competitive distance runners. J Appl Physiol 2008;105:629-636. pdf
Week 6
Plasticity Heat shock proteins pdf
Plasticity Cardiopulmonary pdf
Plasticity Resistance training hypertrophy pdf
Plasticity Muscle plasticity review pdf
Plasticity Myocardial adaptations pdf
Plasticity Muscle detraining on International Space Station pdf
Plasticity Muscle differences between trained and untrained runners pdf
Plasticity Molecular basis of cellular adaptation to training pdf
Week 7
Fatigue & RPE Joseph T. et al. Perception of fatigue during simulated competition. Med Sci Sports Exerc 2008;40(2):381-386.  pdf
Fatigue & Cycling Review Abbis CR & Laursen PB. Models to explain fatigue during prolonged endurance cycling. Sports Med 2005;35(10):3:865-898. pdf
Potassium McKenna MJ et al. Muscle K+, Na+ and Cl- disturbances and Na+-K+ pump inactivation: Implications for fatigue. J Appl Physiol 2008;104:288-295. pdf
Muscle Metabolism & Fatigue Sahin K et al. Energy supply and muscle fatigue in humans. Acta Physiol Scand 1998;162:261-266. pdf
Muscle Metabolism & Fatigue Saltin B et al. Point: In health and in a normoxic environment, VO2max is limited primarily by cardiac output and locomotor muscle blood flow. J Appl Physiol 2006;100:744-748. pdf
Week 8
biopsy vs. 31P MRS Sullivan MJ. et al. Skeletal muscle pH assessed by biochemical and 31P-MRS methods during exercise and recovery in men. J Appl Physiol 1994;77(5):2194-2200. pdf
critical power Jones AM. et al. Muscle metabolic responses to exercise above and below the "critical power" assessed using 31P-MRS. Am J Reg Integr Comp Physiol 2008;294:R585-R593. pdf
creatine loading Smith SA. et al. Use of phosphocreatine kinetics to determine the influence of creatine on muscle mitochondrial respiration: An in vivo 31P-MRS study of oral creatine ingestion. J Appl Physiol 2004;96:2288-2292. pdf
Week 9
Task dependency Weir JP. et al. Is fatigue all in your head? A critical review of the central governor model. Br J Sports Med. 2006;40:573-586. pdf
Lactate-H+ efflux Messonnier L. et al. Importance of pH regulation and lactate/H+ transport capacity for work production during supramaximal exercise in humans. J Appl Physiol 2007;102:1936-1944. pdf
Week 10
Muscle electrical stimulation Spriet LL et al. Anaerobic energy release in skeletal muscle during electrical stimulation in men. J Appl Physiol. 1987;62(2):611-615. pdf
Role of Pi and Ca++ Allen DG and Westerblad H. Role of phosphate and calcium stores in muscle fatigue. J Physiol 2001;536.3:657-665. pdf
31P MRS and acidosis Roussel M et al. Metabolic determinants of the onset of acidosis in exercising human muscle: a 31P MRS study. J Appl Physiol 2003;94:1145-1152. pdf
Week 11
Noakes TD How did AV Hill understand the VO2max and the "plateau phenomenon"? .... pdf
Thomas & Stephane Prefrontal cortex oxygenation and neuromuscular responses to exhaustive .... pdf
Gandevia SC Neural control in human muscle fatigue: changes in muscle afferents, .... pdf
Taylor & Gandevia A comparison of central aspects of fatigue in submaximal and maximal .... pdf
Week 12
Week 13